| IED ID | IndEnz0002001089 |
| Enzyme Type ID | protease001089 |
| Protein Name |
Salivary plasminogen activator alpha 1 EC 3.4.21.68 DSPA alpha-1 |
| Gene Name | |
| Organism | Desmodus rotundus (Vampire bat) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Laurasiatheria Chiroptera Microchiroptera Phyllostomidae (leaf-nosed bats) Desmodontinae Desmodus Desmodus rotundus (Vampire bat) |
| Enzyme Sequence | MVNTMKTKLLCVLLLCGAVFSLPRQETYRQLARGSRAYGVACKDEITQMTYRRQESWLRPEVRSKRVEHCQCDRGQARCHTVPVNSCSEPRCFNGGTCWQAVYFSDFVCQCPAGYTGKRCEVDTRATCYEGQGVTYRGTWSTAESRVECINWNSSLLTRRTYNGRMPDAFNLGLGNHNYCRNPNGAPKPWCYVIKAGKFTSESCSVPVCSKATCGLRKYKEPQLHSTGGLFTDITSHPWQAAIFAQNRRSSGERFLCGGILISSCWVLTAAHCFQESYLPDQLKVVLGRTYRVKPGEEEQTFKVKKYIVHKEFDDDTYNNDIALLQLKSDSPQCAQESDSVRAICLPEANLQLPDWTECELSGYGKHKSSSPFYSEQLKEGHVRLYPSSRCAPKFLFNKTVTNNMLCAGDTRSGEIYPNVHDACQGDSGGPLVCMNDNHMTLLGIISWGVGCGEKDVPGVYTKVTNYLGWIRDNMHL |
| Enzyme Length | 477 |
| Uniprot Accession Number | P98119 |
| Absorption | |
| Active Site | ACT_SITE 272; /note=Charge relay system; ACT_SITE 321; /note=Charge relay system; ACT_SITE 428; /note=Charge relay system |
| Activity Regulation | ACTIVITY REGULATION: Activity toward plasminogen is stimulated in the presence of fibrin I. |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.; EC=3.4.21.68; |
| DNA Binding | |
| EC Number | 3.4.21.68 |
| Enzyme Function | FUNCTION: Probably essential to support the feeding habits of this exclusively haematophagous animal. Potent thrombolytic agent. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Beta strand (18); Chain (1); Disulfide bond (14); Domain (4); Glycosylation (2); Helix (5); Signal peptide (1); Turn (3) |
| Keywords | 3D-structure;Disulfide bond;EGF-like domain;Glycoprotein;Hydrolase;Kringle;Plasminogen activation;Protease;Secreted;Serine protease;Signal |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..36; /evidence=ECO:0000255 |
| Structure 3D | X-ray crystallography (1) |
| Cross Reference PDB | 1A5I; |
| Mapped Pubmed ID | 15685597; |
| Motif | |
| Gene Encoded By | |
| Mass | 53,616 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |