| IED ID | IndEnz0002001092 |
| Enzyme Type ID | protease001092 |
| Protein Name |
Salivary plasminogen activator gamma EC 3.4.21.68 DSPA gamma |
| Gene Name | |
| Organism | Desmodus rotundus (Vampire bat) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Laurasiatheria Chiroptera Microchiroptera Phyllostomidae (leaf-nosed bats) Desmodontinae Desmodus Desmodus rotundus (Vampire bat) |
| Enzyme Sequence | MVNTMKTKLLCVLLLCGAVFSLPRQETYRQLARGSRAYGDPHATCYKDQGVTYRGTWSTSESGAQCINWNSNLLIRRTYNGRMPEAVKLGLGNHNYCRNPDGASKPWCYVIKARKFTSESCSVPVCSKATCGLRKYKEPQLHSTGGLFTDITSHPWQAAIFAQNRRSSGERFLCGGILISSCWVLTAAHCFQERYPPQHLRVVLGRTYRVKPGKEEQTFEVEKCIVHEEFDDDTYNNDIALLQLKSGSPQCAQESDSVRAICLPEANLQLPDWTECELSGYGKHKSSSPFYSEQLKEGHVRLYPSSRCTSKFLFNKTVTNNMLCAGDTRSGEIYPNVHDACQGDSGGPLVCMNDNHMTLLGIISWGVGCGEKDIPGVYTKVTNYLGWIRDNMRP |
| Enzyme Length | 394 |
| Uniprot Accession Number | P49150 |
| Absorption | |
| Active Site | ACT_SITE 189; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 238; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 345; /note=Charge relay system; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.; EC=3.4.21.68; |
| DNA Binding | |
| EC Number | 3.4.21.68 |
| Enzyme Function | FUNCTION: Probably essential to support the feeding habits of this exclusively haematophagous animal. Probable potent thrombolytic agent. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Disulfide bond (9); Domain (2); Glycosylation (1); Signal peptide (1) |
| Keywords | Disulfide bond;Glycoprotein;Hydrolase;Kringle;Plasminogen activation;Protease;Secreted;Serine protease;Signal |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..36; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 44,105 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |