| IED ID | IndEnz0002001095 |
| Enzyme Type ID | protease001095 |
| Protein Name |
SUMO-specific isopeptidase USPL1 EC 3.4.22.- Ubiquitin-specific peptidase-like protein 1 |
| Gene Name | Uspl1 |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MTDDSLKIGNGLPLVGPGTDVGISSLPMLGYLGKNYASAKVTTDGHCPACRAKGKLSALKPYRISFQESVFLCEDLQCIYPLGSESLTNLISPDSEDCPTPSKPQKRKRLETNCRNSPLPVHSKKTRSHIVTDSEPIVNGKYNGEVCDDFSASFPDTSAHQDPASTAASVEQSEALEADDVVVAATEDPATVSVTSELEMPAKSRCLPLCQTLCVQWKNTQALCWLDCILSALVHLEVLRKTVLEACSREECVFGRLFEMYHQADELLHTHHLHGVTGEDCKKLTSEIFTEIDTCLNKVRDEIFAKLQPKLRCTLGDMESPVFALPVLLKLEPHVESLFTYSFSWNFECSHCGHQYQNRCVKSLVTFTNIVPEWHPLNAAHFGPCNSCNSKSQIRKMVLERASPILMLHFVEGLPRRDLQHYAFHFEGSLYQVTSVIQYQANNHFITWFLDADGSWLECDDLKGPCAKRHVTCEVPASETHIVIWERKSQVPIEEAACLPCMKPNVQPVSGEEQPTCPALCSLAGTATSEPSVAHPTSMAGAPQTLPEIQAVAHGDSVLSGAKGMVDSILPSALEETIQETASVSQVDSKDCLLEDKPVAGSAALVRVLAFQPQDSPGSSGSSLVSSLCEGKLVAPCVDSSFPSQAVSTDLQAVLSQAGDTVVPNPVTDAPVPVLVQELKSLATEKDSQTQLLPLKTEKLDPEQPGKSQASNLRKRETTASSKTVAARSAQNQPRKEDQKRAFVGSWVKGLLSRGGAFMPTCVLSQSRAVSDLQPSVKGASNFDGFKTKSISRRSKRMSRKAKHMEELSPRNSSPPLSWTAALTQAAENATSALLREQEGSRPAPLRHRSPGNESAISPASRGDAAEDQVHKLRLKLLKKLKAKKKKLAALISSPHREPSLSDHSEPASHCGTPASDQSEPVSHCGSPNDCESIEDLLKELQHQIDLADSKSGCTSAPDATSNNSQSHEEILAELLSPTAMSEPSESGELELRYLEMGDSTPAQAPSEFSVVSLNTCLKQDHDYCSPEKGQREVDLHSVMDSACIRTLNLGSPMKTDIFDDFFSTSALNSLTNDTLDIPHFDDSLFENC |
| Enzyme Length | 1089 |
| Uniprot Accession Number | Q3ULM6 |
| Absorption | |
| Active Site | ACT_SITE 224; /note=Nucleophile; /evidence=ECO:0000250; ACT_SITE 444; /note=Proton acceptor; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.22.- |
| Enzyme Function | FUNCTION: SUMO-specific isopeptidase involved in protein desumoylation. Specifically binds SUMO proteins with a higher affinity for SUMO2 and SUMO3 which it cleaves more efficiently. Also able to process full-length SUMO proteins to their mature forms (By similarity). Plays a key role in RNA polymerase-II-mediated snRNA transcription in the Cajal bodies (By similarity). Is a component of complexes that can bind to U snRNA genes (By similarity). {ECO:0000250|UniProtKB:Q5W0Q7}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Alternative sequence (3); Chain (1); Compositional bias (2); Domain (1); Modified residue (1); Region (6); Sequence conflict (11) |
| Keywords | Alternative splicing;Hydrolase;Nucleus;Phosphoprotein;Protease;Reference proteome;Thiol protease |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Nucleus, Cajal body {ECO:0000250}. |
| Modified Residue | MOD_RES 894; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:Q5W0Q7 |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 12466851; 12904583; 14610273; 18799693; 19642194; 20019802; 21267068; 21677750; 27869233; |
| Motif | |
| Gene Encoded By | |
| Mass | 118,390 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |