| IED ID | IndEnz0002001106 |
| Enzyme Type ID | protease001106 |
| Protein Name |
Extracellular metalloproteinase 4 EC 3.4.24.- Fungalysin MEP4 |
| Gene Name | MEP4 |
| Organism | Arthroderma otae (Microsporum canis) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Onygenales Arthrodermataceae (dermatophytes) Microsporum Arthroderma otae (Microsporum canis) |
| Enzyme Sequence | MHGLLLAGLLALPSNVLGHPAEPPNSVNVTHRHIDTSAYFLPQLSLYNKSEDVAEYGGDNITGSSYSGGDHSASNLSSEDYVTVATSLLKATLPYASFRLIDDHYIGDSGIGHVHFRQTVYGIDIDNTDFNVNVGRDGKVFSYGSSFYEGEIPKANPVAKRDFSDPVNALIGAINTLNIPVTAAVGEVKTTPIEGNSTYMFKGTTGALTDPTAQLVYLQKDGGLHLTWRVETDVGDNWLLTYVDAKKNDQVHGVVDYVASAEYQVYPWGVNDPTDGERAHLYFPWFKTGSRNWHIDGRGWHTTTRGNNAIAQDNPSGGWEYEDNHRPTNPLLIFRYPYTQSMTPPASYRDASITQLFYTGNVYHDLLYILGFNEKAGNFQVNNWGKGGKGNDFTILNTQDGSGVNNANFATPPDGQPGRMRMYVWDTSTPYRDGSFEAGIVIHEYTHGVSNRLTGGPANSRCLSSLESGGMGEGWSDFFATVVHLKERDTRNKNYTIGEWASGRQGGIRKYPYSTDLHTNPLMYVDADGLESVHAIGTIWCTILNEVLWNLIERHGMGNVNKIKPTFKDGVPTDGRNLAMKLVLDGMALQPCLPNFVQARDAIIDADMNLTKGANRCELWKAFAKRGLGVGAAYNPEKRVGSSRVPGGC |
| Enzyme Length | 649 |
| Uniprot Accession Number | Q6WIH4 |
| Absorption | |
| Active Site | ACT_SITE 444; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.24.- |
| Enzyme Function | FUNCTION: Secreted metalloproteinase probably acting as a virulence factor. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Glycosylation (2); Metal binding (2); Propeptide (1); Signal peptide (1) |
| Keywords | Glycoprotein;Hydrolase;Metal-binding;Metalloprotease;Protease;Secreted;Signal;Virulence;Zinc;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:14766908}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..18; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 71,250 |
| Kinetics | |
| Metal Binding | METAL 443; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095; METAL 447; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095 |
| Rhea ID | |
| Cross Reference Brenda |