Detail Information for IndEnz0002001133
IED ID IndEnz0002001133
Enzyme Type ID protease001133
Protein Name Probable neutral protease 2 homolog MCYG_01991
EC 3.4.24.39
Deuterolysin MCYG_01991
Gene Name MCYG_01991
Organism Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Onygenales Arthrodermataceae (dermatophytes) Microsporum Arthroderma otae (Microsporum canis) Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis)
Enzyme Sequence MQLIATLSALGALVATATAAAVPSAPVKQSVIDIQLSATGNTMIKATITNKGDQALNLLQFNTILDKNPTRKVRVYQNGTEVKFTGMLARYKMTGLSPDYFTTLSPKASVESSFDIARTHDLTRGGKITVMASGTIPTAEGHGANGTTITGYAKYESNKIELDVDAKKAASVVQAMGTVKKSPGSIDKRTNIDTSTCTQSQLDALEGALYNSAALAQAAAQAAPSNLDTVAEYFKSTSRRTINTIVSRLQSVASESTYVNSGSTTYYCTDVMNGCQPGVLAYTLPDQNIITNCPIYYSDLPALAQSCHEQDQATTTLHEMTHNSAVVSPYCDDLGYGYEDATSLSAGQAIQNADTYALFANVS
Enzyme Length 363
Uniprot Accession Number C5FIT1
Absorption
Active Site ACT_SITE 319; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=Preferential cleavage of bonds with hydrophobic residues in P1'. Also 3-Asn-|-Gln-4 and 8-Gly-|-Ser-9 bonds in insulin B chain.; EC=3.4.24.39;
DNA Binding
EC Number 3.4.24.39
Enzyme Function FUNCTION: Probable secreted metalloprotease that shows high activities on basic nuclear substrates such as histone and protamine (By similarity). May be involved in virulence. {ECO:0000250}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (1); Chain (1); Disulfide bond (2); Metal binding (3); Propeptide (1); Signal peptide (1)
Keywords Cleavage on pair of basic residues;Disulfide bond;Hydrolase;Metal-binding;Metalloprotease;Protease;Reference proteome;Secreted;Signal;Virulence;Zinc;Zymogen
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Modified Residue
Post Translational Modification
Signal Peptide SIGNAL 1..19; /evidence=ECO:0000255
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 38,446
Kinetics
Metal Binding METAL 318; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095; METAL 322; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095; METAL 333; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095
Rhea ID
Cross Reference Brenda