IED ID | IndEnz0002001134 |
Enzyme Type ID | protease001134 |
Protein Name |
Neutral protease 2 homolog BDBG_02110 EC 3.4.24.39 Deuterolysin BDBG_02110 |
Gene Name | BDBG_02110 |
Organism | Blastomyces gilchristii (strain SLH14081) (Blastomyces dermatitidis) |
Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Onygenales Ajellomycetaceae Blastomyces Blastomyces gilchristii Blastomyces gilchristii (strain SLH14081) (Blastomyces dermatitidis) |
Enzyme Sequence | MQLSSVLLTAAGLLAPVYSSAIISIGRRSEGLDVSLASTGNTKVQVSVTNTGSSEISILRANTLFDASPTKKFTVYKEGSRKEVPFKGVHLRRSPSDLAKDNLQPIGPGQTIDKEFDLAETLNLSESGTYIVSADGVFPIIDPKSFSIASVIPYESNELKIEVDGKQVSGVLSTRAKIHDHLAQRADFNNGNCTDHQKAVIASALKRDSSIAGEASNAALSGDVRVFEQYFRTTDPSIRQQVSDRFHAISNEACSAEGGVVKYQCEDEMDVCRPGTVAYALLGSNVVVNCPIYYSVTAVSQACDAGDQALTVIHELSHIDAVYYPATTDLAYGEDASMALNADMSIRNADSYTFYANAVRQNCNPS |
Enzyme Length | 366 |
Uniprot Accession Number | C5JHY1 |
Absorption | |
Active Site | ACT_SITE 315; /evidence=ECO:0000250 |
Activity Regulation | |
Binding Site | |
Calcium Binding | |
catalytic Activity | CATALYTIC ACTIVITY: Reaction=Preferential cleavage of bonds with hydrophobic residues in P1'. Also 3-Asn-|-Gln-4 and 8-Gly-|-Ser-9 bonds in insulin B chain.; EC=3.4.24.39; |
DNA Binding | |
EC Number | 3.4.24.39 |
Enzyme Function | FUNCTION: Secreted metalloproteinase that allows assimilation of proteinaceous substrates. Shows high activities on basic nuclear substrates such as histone and protamine (By similarity). {ECO:0000250}. |
Temperature Dependency | |
PH Dependency | |
Pathway | |
nucleotide Binding | |
Features | Active site (1); Chain (1); Disulfide bond (1); Glycosylation (2); Metal binding (2); Propeptide (1); Signal peptide (1) |
Keywords | Cleavage on pair of basic residues;Disulfide bond;Glycoprotein;Hydrolase;Metal-binding;Metalloprotease;Protease;Reference proteome;Secreted;Signal;Zinc;Zymogen |
Interact With | |
Induction | |
Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000250}. |
Modified Residue | |
Post Translational Modification | |
Signal Peptide | SIGNAL 1..19; /evidence=ECO:0000255 |
Structure 3D | |
Cross Reference PDB | - |
Mapped Pubmed ID | - |
Motif | |
Gene Encoded By | |
Mass | 39,271 |
Kinetics | |
Metal Binding | METAL 314; /note=Zinc; catalytic; /evidence=ECO:0000250; METAL 318; /note=Zinc; catalytic; /evidence=ECO:0000250 |
Rhea ID | |
Cross Reference Brenda |