| IED ID | IndEnz0002001139 |
| Enzyme Type ID | protease001139 |
| Protein Name |
Ovochymase-2 EC 3.4.21.- Oviductin |
| Gene Name | Ovch2 Ovtn |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MPISKDKLILILGMVCLEQGHSETLSSIRNPDCGQSLVKPQPQNYFSLFSRIVGGSQVEKGSYPWQVSLKQKQKHICGGTIISSQWVITAAHCMANRNIALTLNVTAGEHDLSQAEPGEQTLAIETIIIHPQFSTRKPMIYDIALLKMAGTFQFGQFVRPVCLPEPGEHFNAGFICTTAGWGRLSEGGRLPQVLQQVNLPILTQEECEAVLLTLKNPITGKTFLCTGSPDGGRDACQGDSGGSLMCQNRKGAWTLAGVTSWGLGCGRSWRNNARKKEQGSPGIFTDLRRVLPWILKHIQTGHRRKSTKALCSEPDGLISGSEGELHFPESLHLYYESKQLCVWTFLVPEDMHMLLNLSHLDIESCHHNYLAMYSLEDRLVGKFCGENLPSSILIGSSSIRLRFISDATDYATGFNLTYKALKPRYHPDSGCRSLTILFEEGTIQSLHYPEDYSNMASCTWIFQAPNYCLIKLSFQSLEIEENGDCSSDYVTVHSDVEKEKEIARFCDYVIPSPVLSSSSVMLISFQSDENGTARGFQADISFISRADLNISISEDESVPLETWDLPPGAMEIFDAERDTHTKPPYEEDIGEMPAIDSGLLKQGERRGKH |
| Enzyme Length | 609 |
| Uniprot Accession Number | Q7M761 |
| Absorption | |
| Active Site | ACT_SITE 92; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 142; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 240; /note=Charge relay system; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.21.- |
| Enzyme Function | FUNCTION: May be required for sperm ADAM3 processing and consequential sperm fertilizing ability (PubMed:32499443). In vitro, has an endopeptidase activity (By similarity). {ECO:0000250|UniProtKB:Q7RTZ1, ECO:0000269|PubMed:32499443}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Alternative sequence (1); Chain (1); Disulfide bond (8); Domain (3); Glycosylation (5); Metal binding (1); Propeptide (1); Region (1); Signal peptide (1) |
| Keywords | Alternative splicing;Calcium;Disulfide bond;Glycoprotein;Hydrolase;Metal-binding;Protease;Reference proteome;Repeat;Secreted;Serine protease;Signal;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P79953}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..22; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 24194600; |
| Motif | |
| Gene Encoded By | |
| Mass | 67,611 |
| Kinetics | |
| Metal Binding | METAL 119; /note=Calcium; /evidence=ECO:0000250 |
| Rhea ID | |
| Cross Reference Brenda | 3.4.21.120; |