IED ID |
IndEnz0002001163 |
Enzyme Type ID |
protease001163 |
Protein Name |
pH-response transcription factor pacC/RIM101
|
Gene Name |
PACC |
Organism |
Penicillium chrysogenum (Penicillium notatum) |
Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Fungi
Dikarya
Ascomycota
saccharomyceta
Pezizomycotina
leotiomyceta
Eurotiomycetes
Eurotiomycetidae
Eurotiales (green and blue molds)
Aspergillaceae
Penicillium
Penicillium chrysogenum species complex
Penicillium chrysogenum (Penicillium notatum)
|
Enzyme Sequence |
MTENHTPSTTQPTLPAPVAEAAPIQANPAPSASVTATAAAATAAVNNAPSMNGAGEQLPCQWVGCTEKSPTAESLYEHVCERHVGRKSTNNLNLTCQWGTCNTTTVKRDHITSHIRVHVPLKPHKCDFCGKAFKRPQDLKKHVKTHADDSEIRSPEPGMKHPDMMFPQNPRGSPAATHYFESPINGINGQYSHAPPPQYYQPHPPPQAPNPHSYGNLYYALSQGQEGGHPYDRKRGYDALNEFFGDLKRRQFDPNSYAAVGQRLLGLQALQLPFLSGPAPEYQQMPAPVAVGGGGGGYGGGAPQPPGYHLPPMSNVRTKNDLINIDQFLEQMQNTIYESDENVAAAGVAQPGAHYVHGGMNHRTTHSPPTHSRQATLLQLPSAPMAAATAHSPSVGTPALTPPSSAQSYTSNRSPISLHSSRVSPPHEEAAPGMYPRLPAAICADSMTAGYPTASGAAPPSTLSGAYDHDDRRRYTGGTLQRARPAERAATEDRMDISQDSKHDGERTPKAMHISASLIDPALSGTSSDPEQESAKRTAATATEVAERDVNVAWVEKVRLLENLRRLVSGLLEAGSLTPEYGVQTSSASPTPGLDAMEGVETASVRAASEQAREEPKSESEGVFYPTLRGVDEDEDGDSKMPE |
Enzyme Length |
643 |
Uniprot Accession Number |
Q01864 |
Absorption |
|
Active Site |
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Activity Regulation |
|
Binding Site |
|
Calcium Binding |
|
catalytic Activity |
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DNA Binding |
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EC Number |
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Enzyme Function |
FUNCTION: Transcription factor that mediates regulation of both acid- and alkaline-expressed genes in response to ambient pH. At alkaline ambient pH, activates transcription of alkaline-expressed genes (including PACC itself) and represses transcription of acid-expressed genes. Specifically recognizes and binds the consensus sequence 5'-GCCARG-3'. {ECO:0000269|PubMed:8736532}. |
Temperature Dependency |
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PH Dependency |
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Pathway |
|
nucleotide Binding |
|
Features |
Chain (1); Compositional bias (4); Motif (2); Region (5); Zinc finger (3) |
Keywords |
Activator;Cytoplasm;DNA-binding;Metal-binding;Nucleus;Repeat;Repressor;Transcription;Transcription regulation;Zinc;Zinc-finger |
Interact With |
|
Induction |
INDUCTION: By alkaline conditions. {ECO:0000269|PubMed:8736532}. |
Subcellular Location |
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. |
Modified Residue |
|
Post Translational Modification |
PTM: Activated by C-terminal proteolytic cleavage by signaling protease (probably palB/RIM13) at neutral to alkaline ambient pH. {ECO:0000250}. |
Signal Peptide |
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Structure 3D |
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Cross Reference PDB |
- |
Mapped Pubmed ID |
- |
Motif |
MOTIF 435..438; /note=YPX[LI] motif 1; MOTIF 625..628; /note=YPX[LI] motif 2 |
Gene Encoded By |
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Mass |
68,823 |
Kinetics |
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Metal Binding |
|
Rhea ID |
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Cross Reference Brenda |
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