| IED ID |
IndEnz0002001164 |
| Enzyme Type ID |
protease001164 |
| Protein Name |
pH-response transcription factor pacC/RIM101
|
| Gene Name |
RIM101 CNBL0920 |
| Organism |
Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Fungi
Dikarya
Basidiomycota
Agaricomycotina
Tremellomycetes
Tremellales (jelly fungi)
Cryptococcaceae
Cryptococcus
Cryptococcus neoformans species complex
Cryptococcus neoformans (Filobasidiella neoformans)
Cryptococcus neoformans var. neoformans
Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans)
|
| Enzyme Sequence |
MAYPTLPPNLLSTPNTYSDSVSPTDPEPITPELVSREPEKPAQKAAKTAMNNTSTASKPSESKGETLPCKWTGCSHISDSPDELYDHLCTVHVGRKSTNNLCLTCGWENCGTKCVKRDHITSHLRVHTPLKPHPCAVCGKTFKRPQDLKKHERIHTAEHHQLHKLSKAPTTADPEFNSRVSLSSATRIDRPRSPLSTSLSPTSTSSHSLHSSSSPFDHLLATGFHTDKSVSPTPSALALLHKKQHEELAAYQQKEMLVLQQLAFNQQQSQAYAARLAAEPFGTGAGAKRGQADAFHDLLSDVKKRKVEPVYDQDMIHRLNALVPPSLPTSFPTLPSLGGYNQYQTFPSFNGYPSLPSLHTSIYPTTAPQAQYSNQSPLPIPEIKTEADLAMFNEFMISLGRDAAANKAGPHPMTQSASGSGASNGYSASNSGTPLSETSGGVEDLFNAEELASLGLAGMPGISIHSGGSHNSNDESTHSLSDASPPAVSFGGLYPSLDAMRNRTNSAPDVSALSGAARRPIAGLPRTSMGNAHNTSTNQSTKPSYLSGMFGHSSSQQYDGTTHNYLHGLSNEHHNDYSHSANNGATNAYASFDSLARNKQSFPAATLAPKMFHNKVYRDVAPLGTAVSKRARESAERTNVEDSDREELYADQESNHGYAVSNERAREERTPKIPVRSLIASIRTLSPSTAADGEDDLKLPAISPSHVEPGTDLPPLYSIQRGGHSSGQYRRASSLSSNSTSTSGSSSFNSSLAPSNVASGTTTPRGSTPPRGVPTKRHTEDEIVRGVKRLELGPAEPLRSTTPELPDSGTTEQALERDQKPDISALSLSSSPTPPSNNPPPSVSTANEEGKDMTIEEMRRRHAALIKSWLVAVNLQWRRKKMEEMQRQQREEMEELEEGGEAMNVDERERERVEVVA |
| Enzyme Length |
917 |
| Uniprot Accession Number |
P0CS63 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Transcription factor that mediates regulation of both acid- and alkaline-expressed genes in response to ambient pH. At alkaline ambient pH, activates transcription of alkaline-expressed genes (including RIM101 itself) and represses transcription of acid-expressed genes (By similarity). {ECO:0000250}. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Chain (1); Coiled coil (1); Compositional bias (9); Motif (1); Region (8); Zinc finger (3) |
| Keywords |
Activator;Coiled coil;Cytoplasm;DNA-binding;Metal-binding;Nucleus;Repeat;Repressor;Transcription;Transcription regulation;Zinc;Zinc-finger |
| Interact With |
|
| Induction |
|
| Subcellular Location |
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. |
| Modified Residue |
|
| Post Translational Modification |
PTM: Activated by C-terminal proteolytic cleavage by signaling protease (probably palB/RIM13) at neutral to alkaline ambient pH. {ECO:0000250}. |
| Signal Peptide |
|
| Structure 3D |
|
| Cross Reference PDB |
- |
| Mapped Pubmed ID |
- |
| Motif |
MOTIF 494..497; /note=YPX[LI] motif |
| Gene Encoded By |
|
| Mass |
99,165 |
| Kinetics |
|
| Metal Binding |
|
| Rhea ID |
|
| Cross Reference Brenda |
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