Detail Information for IndEnz0002001171
IED ID IndEnz0002001171
Enzyme Type ID protease001171
Protein Name Vacuolar membrane protease
EC 3.4.-.-
FXNA-related family protease 1
Gene Name AFUB_006350
Organism Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Eurotiales (green and blue molds) Aspergillaceae Aspergillus Aspergillus subgen. Fumigati Neosartorya fumigata (Aspergillus fumigatus) Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus)
Enzyme Sequence MARPSLSPSNPLGFTPWPVTVITAVVYLALVVPLLVVHHVVPSAPSSSPKGLNLTEAWADLQELTHGFHPYNSHRNDEVHEWLLKRILELIDSAPPASEYGSVGEEKPDIVVFDDTQSNLTFSGRGSGLGVYFESTNIMVYIRGWEEDRERWWEDPHGRPAGKGGVLVNAHYDSVSTGYGATDDGVGVVSCLQLIKYFTTPGHVPRRGLVLLFNNGEEDFLNGARVYSQHPISQLPHTFLNLEGAGAGGRATLFRSSDAEVTKPYMRAPHPFGSVLSANGFEAGLISSQTDYVVFEGDLGLRGLDVAFMEPRARYHTDEDDARHTSLASVWHMLSAAVATTEGLVSDASSRFEGLPREDGRIASGSGPKGVWFDLFGSAFVVFELHTLFALSVTLLVVAPLVLLVTSIALARADKMYLFRSSASPEDSDGSEVVPLHGVRGFFRFPFLLVIPTAVTVGLAYLVTKFNPYIIHSSEYAVWSMMISAWVFLAWFVSRVADFARPSAFHRVYTLTWLFLVEWVFLVISTVYENQYGLAGGYFVLFVFAGTFLATWISYLELFALPRKSDYATQLALPSRRTSSHGSRLGTASGEDVEDGEDEDDDGTTAEATETTSLLRGQRTTFANYVRVTGDYLRDDDEEPRQPNLYGHEQAWSIHLPKWVWVLQFLLTAPLVLIFVGPLALLLTSALRQTGQDGSPSLFIYIAVAALTTLLFIPLLPFIHRYTHHIPLFLLCVFAGTLIYNLVAFPFSPANRLKLFFIQEVDLDTGVNHASLSGAYPFVHDVARRLPSTAGQNITCDLAMLRPKCSWHGIPPQVVQPAAASKMEDWLSYNITKSDSEPKAQLSISGRNTRACKVVFDRPVLDFQVADSAYDPRFPHVSPDGTKEIRLWSREWGHTWTVDVEWAADAEETDEKGPGLSGRVVCLWSDGNSAGVIPALDEVRRYAPVWAGVSKLSDGLVEGSRRFEV
Enzyme Length 965
Uniprot Accession Number B0XPG0
Absorption
Active Site ACT_SITE 217; /note=Proton acceptor; /evidence=ECO:0000250|UniProtKB:P80561
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number 3.4.-.-
Enzyme Function FUNCTION: May be involved in vacuolar sorting and osmoregulation. {ECO:0000250|UniProtKB:P38244}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (1); Chain (1); Compositional bias (1); Glycosylation (4); Metal binding (6); Region (1); Site (1); Topological domain (10); Transmembrane (9)
Keywords Glycoprotein;Hydrolase;Membrane;Metal-binding;Metalloprotease;Protease;Transmembrane;Transmembrane helix;Vacuole;Zinc
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250|UniProtKB:P38244}; Multi-pass membrane protein {ECO:0000255}.
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 106,578
Kinetics
Metal Binding METAL 171; /note=Zinc 1; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 183; /note=Zinc 1; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 183; /note=Zinc 2; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 218; /note=Zinc 2; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 243; /note=Zinc 1; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 316; /note=Zinc 2; catalytic; /evidence=ECO:0000250|UniProtKB:P80561
Rhea ID
Cross Reference Brenda