Detail Information for IndEnz0002001172
IED ID IndEnz0002001172
Enzyme Type ID protease001172
Protein Name Vacuolar membrane protease
EC 3.4.-.-
FXNA-related family protease 1
Gene Name CPC735_004820
Organism Coccidioides posadasii (strain C735) (Valley fever fungus)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Onygenales Onygenales incertae sedis Coccidioides Coccidioides posadasii (Valley fever fungus) Coccidioides posadasii (strain C735) (Valley fever fungus)
Enzyme Sequence MRRSTDPRNLLVRRGPLLVDGESAISELDPGFFPTGDAPKMSSTTRRRFNLIAFTPGPVTVISSLVYLALLIPLLLVHTIVPSAPKSNPKGVDLSEAWNDLQHLTSGFHPYNSHRNDEIHQWLLQRVGHILDASRKAHEDDAMGSVAPDVFVFDDQQSNLTFSGGGVGNKPITGVYFEGKNIIVYIRGLEDDKENWWDSPGGKPKGKGGVLVNAHYDSVSTGFGATDDGVGVVSVLQLIKFFTSPGNLPRKGLVLLLNNGEEDYLNGARAYSQHPLSKYTHTFLNLEGAGAGGRAALFRTTDIEVTRFYKSSPHPFGSVLAADGFKMGLIRSETDYAVFKGVLGLRGLDVAFIEPRARYHTDQDDVRHTSIDSVWHMLSAAIATTKGLVSYTGSEFDGRAPGKGMVNSGVGTHGVWFDLFGSSFAVFRLHTLFAISVTLLVVCPIVLFVIGIILSKMDKMYLFSIHETIPETKEKVSVRGLRGLFRYPIILVVSSGILIGLSYLLAKVNPFIVHSSSYAVWSMMLSSWIFMTWFLSCIADFFRPSALHRAYTFTWQLLVMWVLLVISTVYVNQHDIAAGYFIVFYFAGTFLATLISYLELFALPNKTRYAREQSQYPSRLGSNRSSRILSPSADELPTGGDNNGEIYDGEEEPTESSSLLGRQRRTTFANYTRTGRDLASSESGTYEDHSETGVFGEEQKWSASLPTWTWVLQFLFVGPVVIMFIGQLGLFLTSAMNQVGADGVGLLVVYIAIAVFSVLLLIPLSPFIHRFTYHVPTFLLLVFIATLIYNLAAFPFSAENRLKIFFVQELNLDTGRNQVSLTGVDPYVQDIIRAIPSASKENISCDSELDSGRRKCSWPGLAPEVVQDEPTDRWLSFNISKPSSQETKDTPVLHARLHVSGKNTRACRVNFERPIRDYSLPGSALDDRMPHTLPQGISEIRLWSRTWENVWTVDVQWDAEDMDELHGRVVCLWSDANQLGSIPALDELRLFAPPWVAISKLKDGLVEVSRGF
Enzyme Length 1012
Uniprot Accession Number C5P998
Absorption
Active Site ACT_SITE 261; /note=Proton acceptor; /evidence=ECO:0000250|UniProtKB:P80561
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number 3.4.-.-
Enzyme Function FUNCTION: May be involved in vacuolar sorting and osmoregulation. {ECO:0000250|UniProtKB:P38244}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (1); Chain (1); Compositional bias (1); Glycosylation (3); Metal binding (6); Region (1); Site (1); Topological domain (10); Transmembrane (9)
Keywords Glycoprotein;Hydrolase;Membrane;Metal-binding;Metalloprotease;Protease;Transmembrane;Transmembrane helix;Vacuole;Zinc
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250|UniProtKB:P38244}; Multi-pass membrane protein {ECO:0000255}.
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 112,348
Kinetics
Metal Binding METAL 215; /note=Zinc 1; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 227; /note=Zinc 1; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 227; /note=Zinc 2; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 262; /note=Zinc 2; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 287; /note=Zinc 1; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 360; /note=Zinc 2; catalytic; /evidence=ECO:0000250|UniProtKB:P80561
Rhea ID
Cross Reference Brenda