IED ID | IndEnz0002001175 |
Enzyme Type ID | protease001175 |
Protein Name |
Vacuolar membrane protease EC 3.4.-.- FXNA-related family protease 1 |
Gene Name | ZYRO0G12540g |
Organism | Zygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568 / NRRL Y-229) (Candida mogii) |
Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Saccharomycotina (true yeasts) Saccharomycetes Saccharomycetales Saccharomycetaceae Zygosaccharomyces Zygosaccharomyces rouxii (Candida mogii) Zygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568 / NRRL Y-229) (Candida mogii) |
Enzyme Sequence | MFVDFLRSLFRLRKTNVSILLLLTYLTVGLIYFYDHEHYKHVTPEQSRFKDAPQLVEDAWLNLQNITYSYHPYFSRDNNRVHDYLLNKIEAIAQRSVHVSVSDDASNNRSVLLRNSFVDGGAVYFESSNIVVKIEGKNTDLPGLLLSAHYDGVPTSHGATDDGKGVVSLLGILDHYSRHQPERTLVFNFNNNEEFGLLGAVAFMEHPWSKLVHYVINLEGTGIGGKAVLFRTSDVSTAKIYQNAVKSNPFGNSLFQQGFYEGGVGSETDYRIYESNGLRGFDIAFYKPRDLYHTTKDSVQYTSREALWHMFHTAWQLTEYIAREPIDNDDDFTPAVFFDVAGLFFFSTSSKTLFKWCCVILVVLPVIAFNFDVISFSQKRSSYNQRHRWGVSIRLPLSFASSLLLLRFTERLLSSHNTFILSRGHLTPLIALATEFILSNYLILSFFEYLLPTRDFKTTALRQVAILTWIVLFVCTMKLYKSEYKYTGIYGIVILYSFVSLAGIIGLFGRVLKGNISRESTDNKGDSSRPYGSHGVDEEQQRSGTSAIEESAGNLEDSNNEGPLDVSTTNNSEHIDAEERAPLLGSNPPSVADQPGITNTLKIKAVSVVNYDWSLQFLIAVPITTFIVFGCVDLGLDALKQTIQEGAVATVHVWNLVFLGGILLTLPVLPFAYKFNYLTAMSFLVAFATTLSLCFLQSPFTEGAPLKVRFSQEININNGTDAIVNVYGRKGGFLQPMLQDLPSVKQMSKDVWCQDELNGMERCLYVGYQPNPLDSQRPVSTEDIFSLKVVSNDKNDHDRSRYAPINAELEINVRENRGCTLWFKNQHLDRPPVRQLTVRHSDNTSDLIKSSQGFTQLQLHKLDFDQQKYRVGIQWLPKILLMDGQEDEDNDQLDMQVTCYWGEYDSESLVNGQHLRKLPAFDELLQYSPLNVSYANRDRGLLTITQSIEL |
Enzyme Length | 950 |
Uniprot Accession Number | C5E0G6 |
Absorption | |
Active Site | ACT_SITE 193; /note=Proton acceptor; /evidence=ECO:0000250|UniProtKB:P80561 |
Activity Regulation | |
Binding Site | |
Calcium Binding | |
catalytic Activity | |
DNA Binding | |
EC Number | 3.4.-.- |
Enzyme Function | FUNCTION: May be involved in vacuolar sorting and osmoregulation. {ECO:0000250|UniProtKB:P38244}. |
Temperature Dependency | |
PH Dependency | |
Pathway | |
nucleotide Binding | |
Features | Active site (1); Chain (1); Compositional bias (2); Glycosylation (5); Metal binding (6); Region (1); Site (1); Topological domain (10); Transmembrane (9) |
Keywords | Glycoprotein;Hydrolase;Membrane;Metal-binding;Metalloprotease;Protease;Reference proteome;Transmembrane;Transmembrane helix;Vacuole;Zinc |
Interact With | |
Induction | |
Subcellular Location | SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250|UniProtKB:P38244}; Multi-pass membrane protein {ECO:0000255}. |
Modified Residue | |
Post Translational Modification | |
Signal Peptide | |
Structure 3D | |
Cross Reference PDB | - |
Mapped Pubmed ID | - |
Motif | |
Gene Encoded By | |
Mass | 107,614 |
Kinetics | |
Metal Binding | METAL 149; /note=Zinc 1; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 161; /note=Zinc 1; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 161; /note=Zinc 2; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 194; /note=Zinc 2; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 219; /note=Zinc 1; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 293; /note=Zinc 2; catalytic; /evidence=ECO:0000250|UniProtKB:P80561 |
Rhea ID | |
Cross Reference Brenda |