Detail Information for IndEnz0002001178
IED ID IndEnz0002001178
Enzyme Type ID protease001178
Protein Name Putative Xaa-Pro dipeptidyl-peptidase
X-Pro dipeptidyl-peptidase
EC 3.4.14.11
X-prolyl-dipeptidyl aminopeptidase
X-PDAP
Gene Name SAV_1674
Organism Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
Taxonomic Lineage cellular organisms Bacteria Terrabacteria group Actinobacteria Actinomycetia (high G+C Gram-positive bacteria) Streptomycetales Streptomycetaceae Streptomyces Streptomyces avermitilis Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
Enzyme Sequence MIPPHRCLTDPLLQGSWPGYLPPMPKRARRMRLTTWRSPVTAVIAALLAAFLTPAAAHGAPRESAPVYSYENAIRESVWVDTRLDGDGDGKTDRVAVDVVRPRELARQGRKIPVIMDASPYYSCCGRGNESQKKTYDANGDVVRMPLFYDNYFVPRGYAFVGVDLAGTNRSDGCVDVGGRSDIQSAKAVIDWLNGRAHGYTSRTGTARAKATWTNGRTGMIGKSWDGTVANGVAATGVKGLKTIVPISAISSWYDYYFAKGAPLYDSGPDWLSDYVDSPDARTKCAAVQRKLVDEAPRTGDWTSLWTERDYVKDASKVRASVFLVHGMQDLNVRAKNFGQWWSALAKNGVERKIWLSQTGHVDPFDFRRTAWVDTLHRWFDHELLGYDNGVDREPTADIERHPDQWVTSTLWPPRGTDAVTLRPGTGTQAGVGTLGLRTGSGTETFTDDPRLSETDWAAHIDESTASKAGFVTAPLAGDVRLSGSSKVTVTATPTTSTAHLSAVLVDLGPDTIRDYADGGEGITTLTDRTCWGASTAGDSACFKNTRATTAAVDYTVLSRGWADLGNHASARKGVPLTPGKAYTITLDLAATDHVVPKGHRLALIVAGTDKDLIDPPSSTPTLTLDLARTSARVPLVGGAAAFTRATAQSGTAADATVLDGVREPHTAHRVPGGGL
Enzyme Length 676
Uniprot Accession Number Q82MI6
Absorption
Active Site ACT_SITE 224; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 330; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 361; /note=Charge relay system; /evidence=ECO:0000250
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=Hydrolyzes Xaa-Pro-|- bonds to release unblocked, N-terminal dipeptides from substrates including Ala-Pro-|-p-nitroanilide and (sequentially) Tyr-Pro-|-Phe-Pro-|-Gly-Pro-|-Ile.; EC=3.4.14.11;
DNA Binding
EC Number 3.4.14.11
Enzyme Function
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (3); Chain (1); Compositional bias (1); Region (1)
Keywords Aminopeptidase;Hydrolase;Protease;Reference proteome;Serine protease
Interact With
Induction
Subcellular Location
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 72,714
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda