Detail Information for IndEnz0002001180
IED ID IndEnz0002001180
Enzyme Type ID protease001180
Protein Name RHOMBOID-like protein 4
AtRBL4
EC 3.4.21.-
Gene Name RBL4 At3g53780 F5K20.80
Organism Arabidopsis thaliana (Mouse-ear cress)
Taxonomic Lineage cellular organisms Eukaryota Viridiplantae Streptophyta Streptophytina Embryophyta Tracheophyta Euphyllophyta Spermatophyta Magnoliopsida Mesangiospermae eudicotyledons Gunneridae Pentapetalae rosids malvids Brassicales Brassicaceae Camelineae Arabidopsis Arabidopsis thaliana (Mouse-ear cress)
Enzyme Sequence MGEKDSETAPIWGKTRERERSNNNNIQPMDLESSSSVSGQQRSLTQSRSSYEERGRGVKEFRSWFPWLIPCFVVANVAVFVITMYVNNCPKKSGDCFADFLGRFSFQNTRENPLLGPSSLTLQTMGGLDVKKVVKGDEGWRLLSCNWLHGGVVHLLMNMLTLLFIGIRMEREFGFIRIGLLYLISGFGGSILSALFLRSNISVGASGAVFGLLGGMLSEIFINWTIYSNKVVTIVTLVLIVAVNLGLGVLPGVDNFAHIGGFATGFLLGFVLLIRPHYGWINQRNGPGAKPHRFKIYQGILWTISLLILVAGFIVGLISLFNNVDGNEHCSWCHYLSCVPTSKWSCNREPASCTTTQLGNQLSMTCLRNGKSASYILANPSDSRINSLCVQLCR
Enzyme Length 394
Uniprot Accession Number F4JBM4
Absorption
Active Site ACT_SITE 206; /note=Nucleophile; /evidence=ECO:0000250|UniProtKB:P54493; ACT_SITE 258; /note=Charge relay system; /evidence=ECO:0000250|UniProtKB:P54493
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number 3.4.21.-
Enzyme Function FUNCTION: Probable rhomboid-type serine protease that catalyzes intramembrane proteolysis. {ECO:0000303|PubMed:22007993}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (2); Alternative sequence (1); Chain (1); Compositional bias (2); Erroneous gene model prediction (1); Region (1); Transmembrane (7)
Keywords Alternative splicing;Hydrolase;Membrane;Protease;Reference proteome;Transmembrane;Transmembrane helix
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID 17317660; 18543065; 18650403;
Motif
Gene Encoded By
Mass 43,508
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda