IED ID | IndEnz0002001256 |
Enzyme Type ID | protease001256 |
Protein Name |
Rhomboid-like protease 6 EC 3.4.21.105 |
Gene Name | ROM6 |
Organism | Toxoplasma gondii |
Taxonomic Lineage | cellular organisms Eukaryota Sar Alveolata Apicomplexa Conoidasida Coccidia Eucoccidiorida Eimeriorina Sarcocystidae Toxoplasma Toxoplasma gondii |
Enzyme Sequence | MKKSAGPFIASWRPFVGLPVSLERGRTFSRVLGICTYTPAIRRQMLLSGVSVIPPPLSKNFFRHAHLTGFSPFRSSCRRLFAQNGSDVAPLVSRIPNQSVAPGDTQWSVSPMGVHCEHWLKTRCLPGLPAAVFGSHQQVEAALLQRGLSPAKDASERVRSATREDLVRRERPTSEAGSHPPLPSRSSVSAFQLRSRCDPAVSGPSDSAPCGLSQTSFSLRSSSSSGATTRFSVPAVCPVFLCRSLPRLSGRFSRTRFGKQRKRTEEQEDSKDFDTGPLSSGSIFTVLVGSLLFFDVLRSGLYEHRKLLGAFLMTNAAVFTGWRLAATAGNGTWWTFLMRHFVLCRENLARARIYTFVTSSLSHKSTGHLIFNLFVINQLFRLLSFDLSDRDFASLFGLAALCGGLGHLLVSRQPVLGASAFAYALLWTEATRHSREMFRILPIPFFPLTALQLVQVAMCLEAAMAFLARPAFLARFPASRLLRFAQGISWSGHLGGLAAGCLYSWYKRRVEGDRSWQSFSELCRTYGTSDW |
Enzyme Length | 531 |
Uniprot Accession Number | Q2PP52 |
Absorption | |
Active Site | ACT_SITE 419; /note=Nucleophile; /evidence=ECO:0000250; ACT_SITE 493; /evidence=ECO:0000250 |
Activity Regulation | |
Binding Site | |
Calcium Binding | |
catalytic Activity | CATALYTIC ACTIVITY: Reaction=Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.; EC=3.4.21.105; |
DNA Binding | |
EC Number | 3.4.21.105 |
Enzyme Function | FUNCTION: Putative serine protease involved in intramembrane proteolysis and the subsequent release of polypeptides from their membrane anchors. {ECO:0000250}. |
Temperature Dependency | |
PH Dependency | |
Pathway | |
nucleotide Binding | |
Features | Active site (2); Chain (1); Compositional bias (1); Region (1); Transmembrane (6) |
Keywords | Hydrolase;Membrane;Protease;Serine protease;Transmembrane;Transmembrane helix |
Interact With | |
Induction | |
Subcellular Location | SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
Modified Residue | |
Post Translational Modification | |
Signal Peptide | |
Structure 3D | |
Cross Reference PDB | - |
Mapped Pubmed ID | - |
Motif | |
Gene Encoded By | |
Mass | 58,688 |
Kinetics | |
Metal Binding | |
Rhea ID | |
Cross Reference Brenda |