| IED ID | IndEnz0002001260 |
| Enzyme Type ID | protease001260 |
| Protein Name |
Inactive rhomboid protein 1 iRhom1 Rhomboid family member 1 |
| Gene Name | RHBDF1 |
| Organism | Bos taurus (Bovine) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Laurasiatheria Artiodactyla Ruminantia Pecora Bovidae Bovinae Bos (oxen cattle) Bos taurus (Bovine) |
| Enzyme Sequence | MGEARRDSSSSLQHKKPPWLKLDIPAVVPPAAEEPSFLQPLRRQAFLRSVSMPAEPARVPSPHQEPRRPVLQRQMSITQTIRRGTADWFGVSKDSDSTQKWQRKSIRHCSQRYGKLKPQVIRELDLPSQDNVSLTSTETPPPLYVGPCQLGMQKIVDPLARGRAFRLADDAADGPSAPHTPVTPGAASLCSFSSSRSGFNRLPRRRKRESVAKMSFRAAAALVKGRSVRDGTLRRAQRRSFTPASFLEEDTADFPDELDTSFFAREGVLHEELSTYPDEVFESPSEAALKDWERAPEQVDLTGGALDRSELERSHLMLPLERGWRKQKEGGAAAPQPKVRLRQEVVSTAGQRRGQRIAMPVRKLFAREKRPYGLGMVGRLTNRTYRKRIDSYVKRQIEDMDDHRPFFTYWLTFVHSLVTILAVCIYGVAPVGFSQHETVDSVLRNRGVYENVKYVQQENFWIGPSSEALIHLGAKFSPCMRQDPQVHSFIHAAREREKHSACCVRNDRSGCVQTSEEECSSTLAVWVKWPLHPSAPDLAGQKRRYGSVCHQDPRVCDEPSSEDPHEWPDDITKWPICTKSSAGNHTNHPHMDCVITGRPCCIGTKGRCEITSREYCDFMRGYFHEEATLCSQVHCMDDVCGLLPFLNPEVPDQFYRLWLSLFLHAGVLHCLVSVCFQMTVLRDLEKLAGWHRIAIIYLLSGVTGNLASAIFLPYRAEVGPAGSQFGILACLFVELFQSWQILARPWRAFFKLLAVVLFLFTFGLLPWIDNFAHISGFISGLFLSFAFLPYISFGKFDLYRKRCQIIVFQLVFLGLLAGLVVLFYFYPVRCEWCEFLTCIPFTDKFCEKYELDAQLH |
| Enzyme Length | 856 |
| Uniprot Accession Number | A7YWH9 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. {ECO:0000250|UniProtKB:Q96CC6}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Glycosylation (1); Modified residue (5); Region (1); Topological domain (8); Transmembrane (7) |
| Keywords | Endoplasmic reticulum;Glycoprotein;Golgi apparatus;Growth factor binding;Membrane;Phosphoprotein;Protein transport;Reference proteome;Transmembrane;Transmembrane helix;Transport |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q96CC6}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q96CC6}; Multi-pass membrane protein {ECO:0000255}. Note=Predominantly localized in the endoplasmic reticulum membrane. {ECO:0000250|UniProtKB:Q96CC6}. |
| Modified Residue | MOD_RES 76; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:Q96CC6; MOD_RES 176; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:Q6PIX5; MOD_RES 180; /note=Phosphothreonine; /evidence=ECO:0000250|UniProtKB:Q6PIX5; MOD_RES 183; /note=Phosphothreonine; /evidence=ECO:0000250|UniProtKB:Q6PIX5; MOD_RES 391; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:Q96CC6 |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 97,270 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |