Detail Information for IndEnz0002001260
IED ID IndEnz0002001260
Enzyme Type ID protease001260
Protein Name Inactive rhomboid protein 1
iRhom1
Rhomboid family member 1
Gene Name RHBDF1
Organism Bos taurus (Bovine)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Laurasiatheria Artiodactyla Ruminantia Pecora Bovidae Bovinae Bos (oxen cattle) Bos taurus (Bovine)
Enzyme Sequence MGEARRDSSSSLQHKKPPWLKLDIPAVVPPAAEEPSFLQPLRRQAFLRSVSMPAEPARVPSPHQEPRRPVLQRQMSITQTIRRGTADWFGVSKDSDSTQKWQRKSIRHCSQRYGKLKPQVIRELDLPSQDNVSLTSTETPPPLYVGPCQLGMQKIVDPLARGRAFRLADDAADGPSAPHTPVTPGAASLCSFSSSRSGFNRLPRRRKRESVAKMSFRAAAALVKGRSVRDGTLRRAQRRSFTPASFLEEDTADFPDELDTSFFAREGVLHEELSTYPDEVFESPSEAALKDWERAPEQVDLTGGALDRSELERSHLMLPLERGWRKQKEGGAAAPQPKVRLRQEVVSTAGQRRGQRIAMPVRKLFAREKRPYGLGMVGRLTNRTYRKRIDSYVKRQIEDMDDHRPFFTYWLTFVHSLVTILAVCIYGVAPVGFSQHETVDSVLRNRGVYENVKYVQQENFWIGPSSEALIHLGAKFSPCMRQDPQVHSFIHAAREREKHSACCVRNDRSGCVQTSEEECSSTLAVWVKWPLHPSAPDLAGQKRRYGSVCHQDPRVCDEPSSEDPHEWPDDITKWPICTKSSAGNHTNHPHMDCVITGRPCCIGTKGRCEITSREYCDFMRGYFHEEATLCSQVHCMDDVCGLLPFLNPEVPDQFYRLWLSLFLHAGVLHCLVSVCFQMTVLRDLEKLAGWHRIAIIYLLSGVTGNLASAIFLPYRAEVGPAGSQFGILACLFVELFQSWQILARPWRAFFKLLAVVLFLFTFGLLPWIDNFAHISGFISGLFLSFAFLPYISFGKFDLYRKRCQIIVFQLVFLGLLAGLVVLFYFYPVRCEWCEFLTCIPFTDKFCEKYELDAQLH
Enzyme Length 856
Uniprot Accession Number A7YWH9
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. {ECO:0000250|UniProtKB:Q96CC6}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Chain (1); Glycosylation (1); Modified residue (5); Region (1); Topological domain (8); Transmembrane (7)
Keywords Endoplasmic reticulum;Glycoprotein;Golgi apparatus;Growth factor binding;Membrane;Phosphoprotein;Protein transport;Reference proteome;Transmembrane;Transmembrane helix;Transport
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q96CC6}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q96CC6}; Multi-pass membrane protein {ECO:0000255}. Note=Predominantly localized in the endoplasmic reticulum membrane. {ECO:0000250|UniProtKB:Q96CC6}.
Modified Residue MOD_RES 76; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:Q96CC6; MOD_RES 176; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:Q6PIX5; MOD_RES 180; /note=Phosphothreonine; /evidence=ECO:0000250|UniProtKB:Q6PIX5; MOD_RES 183; /note=Phosphothreonine; /evidence=ECO:0000250|UniProtKB:Q6PIX5; MOD_RES 391; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:Q96CC6
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 97,270
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda