Detail Information for IndEnz0002001272
IED ID IndEnz0002001272
Enzyme Type ID protease001272
Protein Name Cell division inhibitor SulA
Gene Name sulA EFER_1095
Organism Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CCUG 18766 / IAM 14443 / JCM 21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73)
Taxonomic Lineage cellular organisms Bacteria Proteobacteria Gammaproteobacteria Enterobacterales Enterobacteriaceae Escherichia Escherichia fergusonii Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CCUG 18766 / IAM 14443 / JCM 21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73)
Enzyme Sequence MYTSGYANRSSSFSTAVNNTARVATTNTTAGLISEVVYREDQPMMTQLLLLPLLQQLGQQSRWQLWLTPQQKLSREWVQASGLPLSKVMQINQLSPCHTVESMIRALRTGNYSVVIGWLAEELTEEEHAELVNAANEGNAMGFIMRPVSARTHATRQLSGLKIHSNLYH
Enzyme Length 169
Uniprot Accession Number B7LNW8
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division. {ECO:0000255|HAMAP-Rule:MF_01179}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Chain (1); Region (2); Site (1)
Keywords Cell cycle;Cell division;DNA damage;SOS response;Septation
Interact With
Induction INDUCTION: By DNA damage, as part of the SOS response. {ECO:0000255|HAMAP-Rule:MF_01179}.
Subcellular Location
Modified Residue
Post Translational Modification PTM: Is rapidly cleaved and degraded by the Lon protease once DNA damage is repaired. {ECO:0000255|HAMAP-Rule:MF_01179}.
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 18,915
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda