Detail Information for IndEnz0002001273
IED ID IndEnz0002001273
Enzyme Type ID protease001273
Protein Name Cell division inhibitor SulA
Gene Name sulA
Organism Klebsiella aerogenes (Enterobacter aerogenes)
Taxonomic Lineage cellular organisms Bacteria Proteobacteria Gammaproteobacteria Enterobacterales Enterobacteriaceae Klebsiella Klebsiella aerogenes (Enterobacter aerogenes)
Enzyme Sequence MFTSAHANRSPLTSASVRRPSHSVVEHSATGLISEIVYREDQPMMTQLLLLPLLQQLGQQSRWQLWLTPQQKLSKEWVQSSGLPLSKVMQINQMSPCNTLESMIRALRTGNYNVVIGWLTDELTEQEHERLALAAEEGHPMGFIMRPVRNTSQPGRQLSGLKIHSNLYH
Enzyme Length 169
Uniprot Accession Number P08848
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division. {ECO:0000255|HAMAP-Rule:MF_01179}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Chain (1); Region (3); Site (1)
Keywords Cell cycle;Cell division;DNA damage;SOS response;Septation
Interact With
Induction INDUCTION: By DNA damage, as part of the SOS response. {ECO:0000255|HAMAP-Rule:MF_01179}.
Subcellular Location
Modified Residue
Post Translational Modification PTM: Is rapidly cleaved and degraded by the Lon protease once DNA damage is repaired. {ECO:0000255|HAMAP-Rule:MF_01179}.
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 19,180
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda