| IED ID | IndEnz0002001279 |
| Enzyme Type ID | protease001279 |
| Protein Name |
Serine protease/ABC transporter B family protein tagB EC 3.4.21.- Prestalk-specific protein tagB |
| Gene Name | tagB DDB_G0286119 |
| Organism | Dictyostelium discoideum (Slime mold) |
| Taxonomic Lineage | cellular organisms Eukaryota Amoebozoa Evosea Eumycetozoa Dictyostelia (dictyostelid cellular slime molds) Dictyosteliales Dictyosteliaceae Dictyostelium Dictyostelium discoideum (Slime mold) |
| Enzyme Sequence | MKFQFSSPSKIFLFSSVILILIFIGIKFELLEDTNSNRNDKFNNIINRFINYNIDDSIYKNKQQQQQFSNKIYSNEKKILLKNKIIDTTIKPSININNNNNNNNKLNNNNNNNNNNNNNNNNNNNNNNNNNNNNYYNSIEYYSSFVSRLLKSNDDDGIYYDDYQSKYKKNHYIVQFKDRINDETREQLKEFLIGTDITILKEQPFKSHIVHYIPHDSFLVFMTKEQSVLLSSKEWISWIGEHEPSNKIHLNYHEKSIGYPVYIILSGSTNSLIQRWENTLNSILTSYNSKVKLTLINQKKLKSIVYCNDESPSSSSSSSCSLIGSEKIVYKWISEQSESNYIERSEKLQTANRLSPTVIFGTKDKLVNNDRIDIPLRGKGQILSIADTGLDGSHCFFSDSKYPIPFNQVNENHRKVVTYITYHDNEDYVNGHGTHVCGSAAGTPEDSSWAISSFSGLATDAKIAFYDLSSGSSEPTPPEDYSQMYKPLYDAGARVHGDSWGSVSLQGYYGGYSDDAGGIDAFLYEYPEFSILRAAGNNELFASLLAQATAKNAITVGAEQTAHVNYVSDALEYYDFSDNANFQRPCLFDKKYCNYTTAKCCSEVSNVKGLQLCCPASIKQNASDSFTTQPQFYNENNMGSFSSKGPTHDGRLKPDIVAPGEYITSARSNGENSTDQCGDGSLPNANGLMSISGTSMATPLATAATTILRQYLVDGYFPTGESVEENKLLPTGSLLKALMINNAQLLNGTYFWSASSTNPSNAIFEQINGANLIQGWGALRMNNWLYVKSSNPTPPSRWIGIGGLGKNQKATEWKEDSLSSGLNKSYCFTYKPSSSSSGSGGGGGTPRIVATLVWTDPPSYSGAKFNLVNNLDLLLLNSDDDSIITIGNSGGSLQPAGKVAQPDTLNNVEGIIINPTKAMNYKFTIAGTNVPIGPQKFSFVFHGENGQFDWADSCPQCVDGVQFPCLITNGIGIQSCGSDLLWTKCIVQSCNEGYNYNSLKNTCDKFLSYNYIIIIVAGGTMVLIILLLMWIKYQEYKESKRDSFRRFDDGTGIFVRPKDKDAKVTPPDLYNLVSPFIIELTIATACSLVATAASILQPFYIGNIVNNIPTTKSIGEFKSDFIIIFILAFIEFLFTNVGSWISGIVNEKMVMRLQNKVFRALIAQDMGFFQRNNSALLMNVLIVDTPMLRSALTGILLSIATGVCKLVGSLVFIFTISWKLSLAFFAAVPILGLVTQIQSQFTKRLTRQLLFHNSKASQHGTESLTNMHVVTNYCKQEKEMVKYSDQLMNVFITARKLIITNTFAGTGKWLLIESLTFVILYFSAYLVIQKQFTVGLMISFSLYIGYVVDASSSLFGVYVSYIQCLASATRVFMILRSAPRKRTTLEEEEADRLAGLSGGGGGGGDNGDDKKDKQNIENGKDVLPSNIITPIDNVENSNGKQDDPNNNNNNIGNLDYSEQLDGVSTVADSTVGLTKRELKKQKEKEQKEYFKQTGISVAETPTFLPSSYTELTECRGEIEFKNVSFRYPTRPDVQVLHNINMKFEAGKCYGLVGPSGSGKSTTLELISKFYPLHGETGGKIYMDGIDIAKIRPNNLRSFVTNVHQHPFLFDATIGENIGYAIDNPTQEDIIEAAKLAYAHEFINDLPKKYDTQIGEAGNLSGGQKKRIAVARAICAKRKIMLLDEITAELDPESEEAITQSIKVLTQGHTVVMVAHKVAAVRDCDKIFVLEKGYLVEEGTHDELMANKGKYYRMFSEDKDDTPLQNNNNNKNNNNNNNNNEPSSSSTPPNDQPTPPPQEQQEQKNDQPPPPPPQEQQEQQEQQQQQQQEQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQNDQPPNDYDQVPPPPPLPSESPSPPTGNNDGQPLVQMDEENDEER |
| Enzyme Length | 1906 |
| Uniprot Accession Number | P54683 |
| Absorption | |
| Active Site | ACT_SITE 387; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU01240; ACT_SITE 432; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU01240; ACT_SITE 695; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU01240 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.21.- |
| Enzyme Function | FUNCTION: Intercellular communication via tagB may mediate integration of cellular differentiation with morphogenesis. {ECO:0000269|PubMed:7744252}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | NP_BIND 1553..1560; /note=ATP; /evidence=ECO:0000255|PROSITE-ProRule:PRU00434 |
| Features | Active site (3); Chain (1); Compositional bias (5); Domain (3); Glycosylation (8); Nucleotide binding (1); Region (3); Sequence conflict (1); Signal peptide (1); Transmembrane (6) |
| Keywords | ATP-binding;Glycoprotein;Hydrolase;Membrane;Nucleotide-binding;Protease;Reference proteome;Serine protease;Signal;Transmembrane;Transmembrane helix;Transport |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Membrane {ECO:0000255|PROSITE-ProRule:PRU00441}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..31; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 11257439; 12456012; 12871696; 15128662; 15964562; 16107728; 17644489; 17659086; 17905919; 21585358; 21602484; 24726820; 8631494; 8986798; 9190209; 9254905; 9344544; 9435289; 9729606; 9807784; |
| Motif | |
| Gene Encoded By | |
| Mass | 212,647 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |