IED ID | IndEnz0002001280 |
Enzyme Type ID | protease001280 |
Protein Name |
Serine protease/ABC transporter B family protein tagC EC 3.4.21.- Prestalk-specific protein tagC |
Gene Name | tagC DDB_G0286121 |
Organism | Dictyostelium discoideum (Slime mold) |
Taxonomic Lineage | cellular organisms Eukaryota Amoebozoa Evosea Eumycetozoa Dictyostelia (dictyostelid cellular slime molds) Dictyosteliales Dictyosteliaceae Dictyostelium Dictyostelium discoideum (Slime mold) |
Enzyme Sequence | MKFHFSSNKLLLISGLILLVLVIGIKLDIFLSSKSTEYIKFNNNNNHFKRDKRILLHNEIIDTNNKPSIKNNQIFINDNDNNENISPILLRILNNNNNNNNNNGDDKSIYKKNHYIVQFKDRINDETREQLKEFLIGTDIVLDEQPYQSHIVHYIPHDSFLVLMTQEQSVLLSSKEWVSWIGEFEPSNKIHLNYNEKSIGLPVYIILSDSTNSLIQRWENTLNSILKSYNSKVKLTLINQKKLKSIVYCNDESPSPSCSLINSEKLVYQWISEQSESNFIERSEKFQTANRLSPKVVFGTKDTLVNNDRVDIPLRGKGQILSIADTGLDGSHCFFSDSKYPIPLNSVNLNHRKVVTYITTSTSDDSDKVDGHGTHICGSAAGTPEDSSVNISSFSGLATDAKIAFFDLASGSSSLTPPSDLKQLYQPLYDAGARVHCDSWGSVSVEGYTGSYSSDTASIDDFLFTHPDFIILRAAGNNEQYLSLLTQSTAKNVITVGAHQTIHENYLTDGPNYINYQSSVDINQELICDFDSRYCNYTTAQCCLESNATTGLASCCPTLLRKSVIDAANTQPLLYNENNICSFSSKGPTHDGRMKPDLVAPGEYITSARSNGANTTDQCGDGSLPNTNALLAISGTSMATSFAAAATTILRQYLVDGYYPTGSIVESNKLQPTGSLLKALMINNAQLLNGTFQLITSSSITYPSNQVFENFAGASLVQGWGAIRMSNWLHVVNNNNSNNNNKTSDGITKFVGIGGLDLRLVKPNQWKEESLSTGQNTSYCFTYKPSSSSSNSGNNIPRVVATLVWTDPPSYAGAKFNLVNNLDLTMIYYRDNGSTIFYSNQGGSSFLGLAPTQDTLNNVEGIVHNPTEPMTYRFMVAGTNVPMGPQNFSFVFHGENGEFEWADKCPQCSPGQVLACPVENGIGTQLCTSDLQWSSCLIQSCDNNYNYNSIKKRCDKFLSYNYIIMIVAGGTMLLIIFILLLIKYQEYKESKKDSFRRFDDGTGIFVRPKDKDAKVSLADLYNLISPFIIELAISTACSLVSTAASILQPFYIGQIINDIPTAKHIGDFKSQFILIFILAVIEFVFSTISSWISGIVNEKMVMRLQNKVFRALIAQDMGFFQKNNAAILMNVLISDTPMLRSALTGILLSIATGLCKFVGSLVFIFTISWKLSLVFFATVPVLAFITQIQSQFTKRLTRALLFYNSKASQHGQESMVNMHVVTNYCRQDKEIIKYTDNLNNVFQTARRLIINNTLASSIKWLMVESLAFIILYYGAYLAIQKQFTVGLLISFCLYIGYVIDSTTTLFGVYVSYVQSQASATRVFMILRSAPRKRTTLEEEEADRNNGLGGGGGNNNNNDDDDDDDNYNGKGNDNGKGSDDPNNNNNNTTLENIDDNGELTTVQPVELTKKQLKKQKEKEQKEYFKRTGISVVEMSLIPSSYIELTDCKGEIEFKNVSFRYPTRPDVQVLHNINMKFETGKCYGLVGPSGSGKSTLLELISKFYPLRDGGNIIMDDIDIANIRPNNLRGFVTCVHQNPYLFDASIKDNIGYALDNPTIEEVIEAAKLAYAHEFIKDLPQQYDTVLGSAGSLLSGGQKKRIAIARAICAKRKIMLLDEITAELDPESEEAITQSIKVLTQGHTVVMVAHKVAAVRDCDKIFVLDKGYLVEEGTHDELMERKGKYHRMFNNEKDEEELLNNLGLPSNNETNNENNNENNNNNNNNNNNNNNNNDDNNNQVVGEQV |
Enzyme Length | 1741 |
Uniprot Accession Number | Q23868 |
Absorption | |
Active Site | ACT_SITE 325; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU01240; ACT_SITE 372; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU01240; ACT_SITE 637; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU01240 |
Activity Regulation | |
Binding Site | |
Calcium Binding | |
catalytic Activity | |
DNA Binding | |
EC Number | 3.4.21.- |
Enzyme Function | FUNCTION: May be directly involved in maturation and export of SDF-2. The exposure of the protease domain of tagC on the surface of the prestalk cells were it can convert acbA to SDF-2 is induced by GABA. Intercellular communication via tagC may mediate integration of cellular differentiation with morphogenesis. {ECO:0000269|PubMed:16672332, ECO:0000269|PubMed:8986798, ECO:0000269|PubMed:9473320}. |
Temperature Dependency | |
PH Dependency | |
Pathway | |
nucleotide Binding | NP_BIND 1485..1492; /note=ATP; /evidence=ECO:0000255|PROSITE-ProRule:PRU00434 |
Features | Active site (3); Chain (1); Compositional bias (1); Domain (3); Glycosylation (15); Nucleotide binding (1); Region (2); Sequence conflict (3); Signal peptide (1); Transmembrane (6) |
Keywords | ATP-binding;Glycoprotein;Hydrolase;Membrane;Nucleotide-binding;Protease;Reference proteome;Serine protease;Signal;Transmembrane;Transmembrane helix;Transport |
Interact With | |
Induction | |
Subcellular Location | SUBCELLULAR LOCATION: Membrane {ECO:0000255|PROSITE-ProRule:PRU00441}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}. |
Modified Residue | |
Post Translational Modification | |
Signal Peptide | SIGNAL 1..27; /evidence=ECO:0000255 |
Structure 3D | |
Cross Reference PDB | - |
Mapped Pubmed ID | 11784104; 12456012; 15128662; 15897458; 15964562; 17644489; 19823779; 21205784; 24726820; 7744252; 9254905; 9729606; 9807784; |
Motif | |
Gene Encoded By | |
Mass | 193,884 |
Kinetics | |
Metal Binding | |
Rhea ID | |
Cross Reference Brenda |