| IED ID | IndEnz0002001280 |
| Enzyme Type ID | protease001280 |
| Protein Name |
Serine protease/ABC transporter B family protein tagC EC 3.4.21.- Prestalk-specific protein tagC |
| Gene Name | tagC DDB_G0286121 |
| Organism | Dictyostelium discoideum (Slime mold) |
| Taxonomic Lineage | cellular organisms Eukaryota Amoebozoa Evosea Eumycetozoa Dictyostelia (dictyostelid cellular slime molds) Dictyosteliales Dictyosteliaceae Dictyostelium Dictyostelium discoideum (Slime mold) |
| Enzyme Sequence | MKFHFSSNKLLLISGLILLVLVIGIKLDIFLSSKSTEYIKFNNNNNHFKRDKRILLHNEIIDTNNKPSIKNNQIFINDNDNNENISPILLRILNNNNNNNNNNGDDKSIYKKNHYIVQFKDRINDETREQLKEFLIGTDIVLDEQPYQSHIVHYIPHDSFLVLMTQEQSVLLSSKEWVSWIGEFEPSNKIHLNYNEKSIGLPVYIILSDSTNSLIQRWENTLNSILKSYNSKVKLTLINQKKLKSIVYCNDESPSPSCSLINSEKLVYQWISEQSESNFIERSEKFQTANRLSPKVVFGTKDTLVNNDRVDIPLRGKGQILSIADTGLDGSHCFFSDSKYPIPLNSVNLNHRKVVTYITTSTSDDSDKVDGHGTHICGSAAGTPEDSSVNISSFSGLATDAKIAFFDLASGSSSLTPPSDLKQLYQPLYDAGARVHCDSWGSVSVEGYTGSYSSDTASIDDFLFTHPDFIILRAAGNNEQYLSLLTQSTAKNVITVGAHQTIHENYLTDGPNYINYQSSVDINQELICDFDSRYCNYTTAQCCLESNATTGLASCCPTLLRKSVIDAANTQPLLYNENNICSFSSKGPTHDGRMKPDLVAPGEYITSARSNGANTTDQCGDGSLPNTNALLAISGTSMATSFAAAATTILRQYLVDGYYPTGSIVESNKLQPTGSLLKALMINNAQLLNGTFQLITSSSITYPSNQVFENFAGASLVQGWGAIRMSNWLHVVNNNNSNNNNKTSDGITKFVGIGGLDLRLVKPNQWKEESLSTGQNTSYCFTYKPSSSSSNSGNNIPRVVATLVWTDPPSYAGAKFNLVNNLDLTMIYYRDNGSTIFYSNQGGSSFLGLAPTQDTLNNVEGIVHNPTEPMTYRFMVAGTNVPMGPQNFSFVFHGENGEFEWADKCPQCSPGQVLACPVENGIGTQLCTSDLQWSSCLIQSCDNNYNYNSIKKRCDKFLSYNYIIMIVAGGTMLLIIFILLLIKYQEYKESKKDSFRRFDDGTGIFVRPKDKDAKVSLADLYNLISPFIIELAISTACSLVSTAASILQPFYIGQIINDIPTAKHIGDFKSQFILIFILAVIEFVFSTISSWISGIVNEKMVMRLQNKVFRALIAQDMGFFQKNNAAILMNVLISDTPMLRSALTGILLSIATGLCKFVGSLVFIFTISWKLSLVFFATVPVLAFITQIQSQFTKRLTRALLFYNSKASQHGQESMVNMHVVTNYCRQDKEIIKYTDNLNNVFQTARRLIINNTLASSIKWLMVESLAFIILYYGAYLAIQKQFTVGLLISFCLYIGYVIDSTTTLFGVYVSYVQSQASATRVFMILRSAPRKRTTLEEEEADRNNGLGGGGGNNNNNDDDDDDDNYNGKGNDNGKGSDDPNNNNNNTTLENIDDNGELTTVQPVELTKKQLKKQKEKEQKEYFKRTGISVVEMSLIPSSYIELTDCKGEIEFKNVSFRYPTRPDVQVLHNINMKFETGKCYGLVGPSGSGKSTLLELISKFYPLRDGGNIIMDDIDIANIRPNNLRGFVTCVHQNPYLFDASIKDNIGYALDNPTIEEVIEAAKLAYAHEFIKDLPQQYDTVLGSAGSLLSGGQKKRIAIARAICAKRKIMLLDEITAELDPESEEAITQSIKVLTQGHTVVMVAHKVAAVRDCDKIFVLDKGYLVEEGTHDELMERKGKYHRMFNNEKDEEELLNNLGLPSNNETNNENNNENNNNNNNNNNNNNNNNDDNNNQVVGEQV |
| Enzyme Length | 1741 |
| Uniprot Accession Number | Q23868 |
| Absorption | |
| Active Site | ACT_SITE 325; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU01240; ACT_SITE 372; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU01240; ACT_SITE 637; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU01240 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.21.- |
| Enzyme Function | FUNCTION: May be directly involved in maturation and export of SDF-2. The exposure of the protease domain of tagC on the surface of the prestalk cells were it can convert acbA to SDF-2 is induced by GABA. Intercellular communication via tagC may mediate integration of cellular differentiation with morphogenesis. {ECO:0000269|PubMed:16672332, ECO:0000269|PubMed:8986798, ECO:0000269|PubMed:9473320}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | NP_BIND 1485..1492; /note=ATP; /evidence=ECO:0000255|PROSITE-ProRule:PRU00434 |
| Features | Active site (3); Chain (1); Compositional bias (1); Domain (3); Glycosylation (15); Nucleotide binding (1); Region (2); Sequence conflict (3); Signal peptide (1); Transmembrane (6) |
| Keywords | ATP-binding;Glycoprotein;Hydrolase;Membrane;Nucleotide-binding;Protease;Reference proteome;Serine protease;Signal;Transmembrane;Transmembrane helix;Transport |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Membrane {ECO:0000255|PROSITE-ProRule:PRU00441}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..27; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 11784104; 12456012; 15128662; 15897458; 15964562; 17644489; 19823779; 21205784; 24726820; 7744252; 9254905; 9729606; 9807784; |
| Motif | |
| Gene Encoded By | |
| Mass | 193,884 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |