| IED ID | IndEnz0002001308 |
| Enzyme Type ID | protease001308 |
| Protein Name |
Vacuolar membrane protease EC 3.4.-.- FXNA-related family protease 1 |
| Gene Name | HCDG_00617 |
| Organism | Ajellomyces capsulatus (strain H143) (Darling's disease fungus) (Histoplasma capsulatum) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Onygenales Ajellomycetaceae Histoplasma Ajellomyces capsulatus (Darling's disease fungus) (Histoplasma capsulatum) Ajellomyces capsulatus (strain H143) (Darling's disease fungus) (Histoplasma capsulatum) |
| Enzyme Sequence | MASSRAQRFNPIAFTPWPVTCITTIVYLALLIPILVINLVVPSAPETNPKGVNLTEAWRDLQHLTGGFHPYNSRRNDEVHEWLLSRINSIIRPTVEAGQRSSATDNLPEVFVFDDNRSNLTYSNGGVGKTSIVGVYFESTNIIVYIRGSEDDSENWRERSNGKPKGKGGVLVNAHYDSVSTGYGATDDGIGVVSLLQLLRYFTTPGNNPRKGLVLLFNNGEEDYLNGAHVFSQHPLSNFTHTFLNLEDTEVTRFYGNTKHPFGSVLAADGFKMGLLRSQTDYVVFNGILGLRGLDLAFIAPRSRYHTDQDDTRHTSIDSLWHMLSASIGTTEGLVSYTGMDFDGKSKGQNKVNSGAGSLGVWFDMFGTAFAVFRLHTLFAISVALLVIAPLVIFITSVILSKTDRMYLFSMSKSLEGTGDQVSLRGLRGFSRTPIILVIATTIPICLAYLLEKVNPYIVHSSQFSVWSMMFSAWIFLAWFLACAADFFRPSALHRAYSYTWIFVATWIMLVINTVYANQKGIAAGYFLLFYFAGAFLATWISYLELFALPRKGDFARQTTGRRPSSLSSRLLTSSADELRSNASPSTAEFPGAAGEDTDPTESTSLLRGQRTTFANYRTSGPGGAAEETDEREDINKGGTFEHEQSWSWTLPRWTWVLQLLLLAPIVLILVGQLALFLTASMCQVGSDGVSTFVVYLACAVFTTLLCIPLFPLIHRFTYHIPTFLFLVFIGTLIYNLVAFPFSPANRLKTFFIQEVDLDNGSSTVSLTGIQPYLTEAINSIPSAAGQNITCDKTTPFGMLERCSWSGLSPNVLGQGRERDTEIVPDKWITYNITKTVGKNKARIEISGRNTRACKLKFDRAVANFQVSGSAVDHRMPPTSRQGPGVIPALDEVRLYAPSWIAISKAADGLVEASHSFTIQ |
| Enzyme Length | 920 |
| Uniprot Accession Number | C6H1N5 |
| Absorption | |
| Active Site | ACT_SITE 221; /note=Proton acceptor; /evidence=ECO:0000250|UniProtKB:P80561 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.-.- |
| Enzyme Function | FUNCTION: May be involved in vacuolar sorting and osmoregulation. {ECO:0000250|UniProtKB:P38244}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Compositional bias (1); Glycosylation (7); Metal binding (6); Region (1); Site (1); Topological domain (10); Transmembrane (9) |
| Keywords | Glycoprotein;Hydrolase;Membrane;Metal-binding;Metalloprotease;Protease;Reference proteome;Transmembrane;Transmembrane helix;Vacuole;Zinc |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250|UniProtKB:P38244}; Multi-pass membrane protein {ECO:0000255}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 101,617 |
| Kinetics | |
| Metal Binding | METAL 175; /note=Zinc 1; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 187; /note=Zinc 1; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 187; /note=Zinc 2; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 222; /note=Zinc 2; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 247; /note=Zinc 1; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 306; /note=Zinc 2; catalytic; /evidence=ECO:0000250|UniProtKB:P80561 |
| Rhea ID | |
| Cross Reference Brenda |