| IED ID | IndEnz0002001314 |
| Enzyme Type ID | protease001314 |
| Protein Name |
Collagenase EC 3.4.-.- Fragment |
| Gene Name | prtC |
| Organism | Porphyromonas gingivalis |
| Taxonomic Lineage | cellular organisms Bacteria FCB group Bacteroidetes/Chlorobi group Bacteroidetes Bacteroidia Bacteroidales Porphyromonadaceae Porphyromonas Porphyromonas gingivalis |
| Enzyme Sequence | DLYKIAEICRDKGVKSYLTVNTVIYDEDMTLMRSVIDAAQKAQISAIIASDVAAMTYANEIGVEVHLSTQLNISNAEALRFIALAMWSYWQRAEYGSGTYNPRDHRQGHICGPKGHPVRIEMFAHGALCMAVSGKCYLSLHEHNTSANRGACAQICRRGYTVKDSGLELDIENQYIMSPKDLKTIHFINKMMDAGVRVFKIEGRARGPEYVYTVCRCYKEAIEAYCNGTYDEESIGRWDEQLATVFNRGFWDGYYLGQRLGEWTHRYGSGRTRQKTYVGKGIKYFSRLGVAEFEIESGELHIGDEIVITGPTTGVIIQKVEEIRYELQTVEKATKGQRISIPVKEKVRPSDKLYRFDKREE |
| Enzyme Length | 361 |
| Uniprot Accession Number | P33437 |
| Absorption | |
| Active Site | |
| Activity Regulation | ACTIVITY REGULATION: Activity somewhat enhanced by calcium ions, inhibited by zinc and Fe(3+) ions and by p-chloromercuribenzoic acid and EDTA. Activity is enhanced by salivary peptide cystatin and reduced by salivary peptide histatin. {ECO:0000269|PubMed:1317840}. |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.-.- |
| Enzyme Function | FUNCTION: Has collagenase activity. Active on soluble collagen, reconstituted type I collagen, heat denatured type I collagen and azocoll, but not gelatin or the synthetic bacterial collagenase substrate PZ-PLGPA. May play a role in virulence. {ECO:0000269|PubMed:1317840}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Erroneous initiation (1); Non-terminal residue (1) |
| Keywords | Hydrolase;Protease;Virulence |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 41,055 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |