Detail Information for IndEnz0002001328
IED ID IndEnz0002001328
Enzyme Type ID protease001328
Protein Name Probable tripeptidyl-peptidase SED3
EC 3.4.14.10
Sedolisin-C
Gene Name SED3 ARB_04677/ARB_04678
Organism Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Onygenales Arthrodermataceae (dermatophytes) Trichophyton Arthroderma benhamiae (Trichophyton mentagrophytes) Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes)
Enzyme Sequence MLLRWHSVIPLFLAMTVAFPNTYRTVVEDLPAIPEGWVQGNPPSPETSVRMNLAVGQQNTRTFEQIVLDISTPGHRNYGKHLSRRDLKGLLRPRRETSNLILSWLEKSGVPKRSIVDDGDWIHFVISISQAERMLQTRFYHFHDVQDPGISMIRTLKYSVPSRLARHVYMIQPTTKFGKPKKHANSIANLQAIYLSTNATENCNATITPRCLRELYKMGDYVAKPDCRNVIGVSGYLDQYARYSDFYKFLELYAPEMKGANFSVAHIGNGQNLQNSTRNSIEASLDIEYALGLSNASAVFYTTSGRGPLVPDLDQPEQEHNSNEPYLDQLHYLLSLPQEALPAVLSTSYGENEQSVPERFSHATCNLFAQLGARGVSVIFSSGDSGVGSSCLTNDKKKITRFNPTFPASCPFVTSVGATFKINPERATGFSSGGFSDRHSRPGYQNDAVQHYLDKLGDRWKGLYNPKGRGIPDVSAQGANFAIYDHGKVIIVSGTSASAPAFAAIIANLNAIRLRANKPVLGYLNPFIYGKGREGFTDIVHGGSKGCVGYSSTNRSTPAVPYASWNATEGWDPVTGVGTPNFRILAKIVQHME
Enzyme Length 593
Uniprot Accession Number D4AK75
Absorption
Active Site ACT_SITE 282; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 286; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 496; /note=Charge relay system; /evidence=ECO:0000250
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=Release of an N-terminal tripeptide from a polypeptide.; EC=3.4.14.10;
DNA Binding
EC Number 3.4.14.10
Enzyme Function FUNCTION: Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence. {ECO:0000250}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (3); Chain (1); Domain (1); Erroneous gene model prediction (1); Frameshift (2); Glycosylation (6); Metal binding (4); Propeptide (1); Signal peptide (1)
Keywords Calcium;Glycoprotein;Hydrolase;Metal-binding;Protease;Reference proteome;Secreted;Serine protease;Signal;Virulence;Zymogen
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000250}.
Modified Residue
Post Translational Modification
Signal Peptide SIGNAL 1..18; /evidence=ECO:0000255
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 65,507
Kinetics
Metal Binding METAL 538; /note=Calcium; /evidence=ECO:0000250; METAL 539; /note=Calcium; via carbonyl oxygen; /evidence=ECO:0000250; METAL 570; /note=Calcium; via carbonyl oxygen; /evidence=ECO:0000250; METAL 572; /note=Calcium; /evidence=ECO:0000250
Rhea ID
Cross Reference Brenda