Detail Information for IndEnz0002001329
IED ID IndEnz0002001329
Enzyme Type ID protease001329
Protein Name Tyrosine-protein kinase transforming protein RYK
EC 2.7.10.1
Gene Name V-RYK
Organism Avian retrovirus RPL30
Taxonomic Lineage Viruses Riboviria Pararnavirae Artverviricota Revtraviricetes Ortervirales Retroviridae Orthoretrovirinae Alpharetrovirus Avian leukosis virus (ALV) Avian retrovirus RPL30
Enzyme Sequence TTTVVNYTAKKSYCRRAVELTLGSLGVSSELQQKLQDVVIDRNALSLGKVLGEGEFGSVMEGRLSQPEGTPQKVAVKTMKLDNFSHREIEEFLSEAACIKDFDHPNVIKLLGVCIELSSQQIPKPMVVLPFMKYGDLHSFLLRSRLEMAPQFVPLQMLLKFMVDIALGMEYLSSRQFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTTKSDVWAFGVTMWEIATRGMTPYPGVQNHEIYEYLFHGQRLKKPENCLDELYDIMSSCWRAEPADRPTFSQLKVHLEKLLESLPAPRGSKDVIYVNTSLPEESPDSTQDLGLDSVIPQADSDLDPGDIAEPCCSHTKAALVAVDIHDGGSRYVLESEGSPTEDAYVPQLPHEGSAWTEASTLPVGSSLAAQLPCADGCLEDSEALL
Enzyme Length 442
Uniprot Accession Number P33497
Absorption
Active Site ACT_SITE 181; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028"
Activity Regulation
Binding Site BINDING 77; /note=ATP; /evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence={ECO:0000255|PROSITE-ProRule:PRU10028};
DNA Binding
EC Number 2.7.10.1
Enzyme Function
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding NP_BIND 51..59; /note=ATP; /evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Features Active site (1); Binding site (1); Chain (1); Domain (1); Erroneous initiation (1); Modified residue (1); Nucleotide binding (1)
Keywords ATP-binding;Host cell membrane;Host membrane;Kinase;Membrane;Nucleotide-binding;Oncogene;Phosphoprotein;Transferase;Tyrosine-protein kinase
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Host cell membrane.
Modified Residue MOD_RES 212; /note=Phosphotyrosine; by autocatalysis; /evidence=ECO:0000250
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 49,108
Kinetics
Metal Binding
Rhea ID RHEA:10596
Cross Reference Brenda 2.7.10.1;