Detail Information for IndEnz0002001334
IED ID IndEnz0002001334
Enzyme Type ID protease001334
Protein Name Carboxypeptidase S1 homolog A
EC 3.4.16.6
Serine carboxypeptidase A
SCPA
Gene Name SCPA TRV_05031
Organism Trichophyton verrucosum (strain HKI 0517)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Onygenales Arthrodermataceae (dermatophytes) Trichophyton Trichophyton verrucosum (Cattle ringworm fungus) Trichophyton verrucosum (strain HKI 0517)
Enzyme Sequence MRLAASIAVALPVIGAASAQGFPPPVTGVTVVKSKYDENVKITYKENDICETTEGVRSFTGHVHLPPDNDYFGVYQNYSINTFFWFFEAREDPKNAPLSIWLNGGPGSSSMIGLFQENGPCWINDDSKSTTNNSFSWNNRVNMLYIDQPNQVGFSYDELTNITYSTINDTISVADFSSGVPAQNLSTLVGTGSSQKPWATANNTVNAARSIWHFAQVWFQEFPEHKPNNNKISIWTESYGGRYGPSFASYFQEQNEKIKNHTITKEGEMHILNLDTLGVINGCIDLMFQAESYAEFPYNNTYGITAYTKEKRDAIIRDIHRPDGCFDKLAKCREAAKEGDPHFYSNNATVNAICAEANSDCDKYLMEPFQEANLGYYDIAHPLQDPFPPPFFKGFLSQSSVLSDMGSPVNFSHYSQAVGKSFHGVGDYARPDVRGFTGDIAYLLESGVKVALVYGDRDYICNWLGGEQVSLGLNYTGTEAFRKAGYADVKVNSSYVGGLVRQHGNFSFTRVFEAGHEVPGYQPETSLKIFERIMFNKDIATGELDIAQKQDYGTTGTESTFQVKNEIPPSPEPTCYLLSADGTCTPEQLNAIENGTAVVENYIIKSPAASKGNPPPTTTSSPTASPTAGSAMLKAPVAMLAISALTVLAFYL
Enzyme Length 652
Uniprot Accession Number D4DD24
Absorption
Active Site ACT_SITE 238; /evidence=ECO:0000255|PROSITE-ProRule:PRU10074; ACT_SITE 458; /evidence=ECO:0000255|PROSITE-ProRule:PRU10074; ACT_SITE 516; /evidence=ECO:0000255|PROSITE-ProRule:PRU10074
Activity Regulation
Binding Site BINDING 461; /note=Substrate; /evidence=ECO:0000250; BINDING 517; /note=Substrate; /evidence=ECO:0000250
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=Preferential release of a C-terminal arginine or lysine residue.; EC=3.4.16.6;
DNA Binding
EC Number 3.4.16.6
Enzyme Function FUNCTION: Extracellular serine carboxypeptidase that contributes to pathogenicity. {ECO:0000250}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (3); Binding site (2); Chain (1); Compositional bias (1); Disulfide bond (3); Glycosylation (14); Lipidation (1); Propeptide (1); Region (1); Signal peptide (1)
Keywords Carboxypeptidase;Cell membrane;Disulfide bond;GPI-anchor;Glycoprotein;Hydrolase;Lipoprotein;Membrane;Protease;Signal;Virulence
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}.
Modified Residue
Post Translational Modification
Signal Peptide SIGNAL 1..19; /evidence=ECO:0000255
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 71,675
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda