Detail Information for IndEnz0002001350
IED ID IndEnz0002001350
Enzyme Type ID protease001350
Protein Name Subtilisin-like protease 2
EC 3.4.21.-
Gene Name SUB2
Organism Trichophyton verrucosum (Cattle ringworm fungus)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Onygenales Arthrodermataceae (dermatophytes) Trichophyton Trichophyton verrucosum (Cattle ringworm fungus)
Enzyme Sequence MQLLNFGLLLLPFVAGDLAPQPEPLLAGPSDVVPGQYIVTLKEGLTSAQIRDHKKWVSSVHRANLDSFAAGASGVETEGIMKHFHIHDLNMYSGGFDEKTVEDLSRNPYVKSVHPDQHVYLAKTVTQRQARWGLGYMSSKGKPVPLHSTLVDYSYDDKAGEGVWAYVLDTGINVNHIEFEGRAILGHNAIPNKPHTDEFGHGTYVAGIIAGKTYGVAKKANVVSAKAFDTGSSTYNYILETYDWIVRNITDSNRKNKAVINLSISGAKYQPFDDAVEKAFKAGITTVVAAGNDGKDAKNNTPASSPNAITVGAVRWENTRPSFSNYGKLVDIWAPGELIKSCWKGGNNATSTQSGTSAASPHVAGLVAYLMSIENLPSPSAVTARVLNLTIPNLVKDAKDSPNRVAYNGIQERKFKLPK
Enzyme Length 419
Uniprot Accession Number Q5VJ76
Absorption
Active Site ACT_SITE 169; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU01240; ACT_SITE 201; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU01240; ACT_SITE 357; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU01240
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number 3.4.21.-
Enzyme Function FUNCTION: Secreted subtilisin-like serine protease with keratinolytic activity that contributes to pathogenicity. {ECO:0000250}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (3); Chain (1); Domain (2); Erroneous gene model prediction (1); Glycosylation (4); Propeptide (1); Signal peptide (1)
Keywords Glycoprotein;Hydrolase;Protease;Secreted;Serine protease;Signal;Virulence;Zymogen
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Modified Residue
Post Translational Modification
Signal Peptide SIGNAL 1..16; /evidence=ECO:0000255
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 45,337
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda