Detail Information for IndEnz0002001353
IED ID IndEnz0002001353
Enzyme Type ID protease001353
Protein Name Signal peptide peptidase-like 3
OsSPPL3
EC 3.4.23.-
Gene Name SPPL3 Os01g0914700 LOC_Os01g68620 OsJ_04526 P0004D12.11
Organism Oryza sativa subsp. japonica (Rice)
Taxonomic Lineage cellular organisms Eukaryota Viridiplantae Streptophyta Streptophytina Embryophyta Tracheophyta Euphyllophyta Spermatophyta Magnoliopsida Mesangiospermae Liliopsida Petrosaviidae commelinids Poales Poaceae BOP clade Oryzoideae Oryzeae Oryzinae Oryza Oryza sativa (Rice) Oryza sativa subsp. japonica (Rice)
Enzyme Sequence MAFPAPSSSSPRRRGRGLAYLLVSVLLLASRVPGAAGADSEFEDGVSPKFPGCDNPFQKVKVTYWVDGDERSSLTGITARFGEVLPATGSDGDKRKAVVPAPKTGCAKSSAPLASSIAVAERGECTFLEKAKTAESGGAAALLLINDEDDLQKMVCTQNDTVPNIGIPVVMVSQSAGRKILSGMDGGAKVDILMYAPEKPSFDGAIPFLWLMAVGSVACASVWSFVVVGDEDKNAPTLGGEEAADSEIVELQTKTALVFIVTASLVLLFLFFFKSTWSAWLLVVLFCLSGLQGLHYVASTLIVRTCDRCREAKVALPVLGNVTVVTLVILPLALIFVVVWAVHQNSPFAWVGQDLMGICMMILVLQVVHLPNIKVATALLVSAFMYDIFWVFISPFIFKKSVMITVARGSDEGPSLPMVLKMPKEFDTWNGYDMIGFGDILFPGLLVAFSFRYDRANGKDLTDGYFLCLMIGYAFGLSCTYVGLYLMKSGQPALLYLVPSTLGTIVTLGAKRGELSQLWNAKV
Enzyme Length 523
Uniprot Accession Number Q5N808
Absorption
Active Site ACT_SITE 387; /evidence=ECO:0000250; ACT_SITE 439; /evidence=ECO:0000250
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number 3.4.23.-
Enzyme Function FUNCTION: Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. {ECO:0000250}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (2); Chain (1); Domain (1); Glycosylation (1); Motif (1); Signal peptide (1); Topological domain (10); Transmembrane (9)
Keywords Endosome;Glycoprotein;Hydrolase;Membrane;Protease;Reference proteome;Signal;Transmembrane;Transmembrane helix
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Modified Residue
Post Translational Modification PTM: Glycosylated. {ECO:0000250}.
Signal Peptide SIGNAL 1..35; /evidence=ECO:0000255
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif MOTIF 492..494; /note=PAL
Gene Encoded By
Mass 56,200
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda