| IED ID | IndEnz0002001353 |
| Enzyme Type ID | protease001353 |
| Protein Name |
Signal peptide peptidase-like 3 OsSPPL3 EC 3.4.23.- |
| Gene Name | SPPL3 Os01g0914700 LOC_Os01g68620 OsJ_04526 P0004D12.11 |
| Organism | Oryza sativa subsp. japonica (Rice) |
| Taxonomic Lineage | cellular organisms Eukaryota Viridiplantae Streptophyta Streptophytina Embryophyta Tracheophyta Euphyllophyta Spermatophyta Magnoliopsida Mesangiospermae Liliopsida Petrosaviidae commelinids Poales Poaceae BOP clade Oryzoideae Oryzeae Oryzinae Oryza Oryza sativa (Rice) Oryza sativa subsp. japonica (Rice) |
| Enzyme Sequence | MAFPAPSSSSPRRRGRGLAYLLVSVLLLASRVPGAAGADSEFEDGVSPKFPGCDNPFQKVKVTYWVDGDERSSLTGITARFGEVLPATGSDGDKRKAVVPAPKTGCAKSSAPLASSIAVAERGECTFLEKAKTAESGGAAALLLINDEDDLQKMVCTQNDTVPNIGIPVVMVSQSAGRKILSGMDGGAKVDILMYAPEKPSFDGAIPFLWLMAVGSVACASVWSFVVVGDEDKNAPTLGGEEAADSEIVELQTKTALVFIVTASLVLLFLFFFKSTWSAWLLVVLFCLSGLQGLHYVASTLIVRTCDRCREAKVALPVLGNVTVVTLVILPLALIFVVVWAVHQNSPFAWVGQDLMGICMMILVLQVVHLPNIKVATALLVSAFMYDIFWVFISPFIFKKSVMITVARGSDEGPSLPMVLKMPKEFDTWNGYDMIGFGDILFPGLLVAFSFRYDRANGKDLTDGYFLCLMIGYAFGLSCTYVGLYLMKSGQPALLYLVPSTLGTIVTLGAKRGELSQLWNAKV |
| Enzyme Length | 523 |
| Uniprot Accession Number | Q5N808 |
| Absorption | |
| Active Site | ACT_SITE 387; /evidence=ECO:0000250; ACT_SITE 439; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.23.- |
| Enzyme Function | FUNCTION: Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Domain (1); Glycosylation (1); Motif (1); Signal peptide (1); Topological domain (10); Transmembrane (9) |
| Keywords | Endosome;Glycoprotein;Hydrolase;Membrane;Protease;Reference proteome;Signal;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | PTM: Glycosylated. {ECO:0000250}. |
| Signal Peptide | SIGNAL 1..35; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | MOTIF 492..494; /note=PAL |
| Gene Encoded By | |
| Mass | 56,200 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |