Detail Information for IndEnz0002001354
IED ID IndEnz0002001354
Enzyme Type ID protease001354
Protein Name Tubulointerstitial nephritis antigen
TIN-Ag
Gene Name TINAG
Organism Bos taurus (Bovine)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Laurasiatheria Artiodactyla Ruminantia Pecora Bovidae Bovinae Bos (oxen cattle) Bos taurus (Bovine)
Enzyme Sequence MCAGYKILILAYLTTEIWMERQYLSQREVDPGAEFTRNHTISEGTRFKRAVFEGQYCRRFGCCADRDDGCVTQFYEADALCYCDKFCERENSDCCPDYKSFCREEKGWPPRTKPWSPEGCHRDGQHYEEGSVIKENCNSCTCSGQQWKCSQHVCLVQPGLIEHVNKGDYGWTAQNYSQFWGMTLEEGFKYRLGTLPPSPLLLSMNEVTASLTKTTDLPEFFIASYKWPGWTHGPLDQKNCAASWAFSTASVAADRIAIQSQGRYTANLSPQNLISCCAKKRHGCNSGSVDRAWWYLRKRGLVSHACYPLFKDQNATNNGCAMASRSDGRGKRHATTPCPNSIEKSNRIYQCSPPYRVSSNETEIMREIMQNGPVQAIMQVHEDFFNYKTGIYRHITSTNEDSEKYRKFRTHAVKLTGWGTLRGAQGQKEKFWIAANSWGKSWGENGYFRILRGVNESDIEKLIIAAWGQLTSADEP
Enzyme Length 476
Uniprot Accession Number Q3SZI1
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: Mediates adhesion of proximal tubule epithelial cells via integrins alpha3-beta1 and alphaV-beta3. This is a non catalytic peptidase C1 family protein (By similarity). {ECO:0000250}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Chain (1); Disulfide bond (2); Domain (1); Glycosylation (5); Site (1)
Keywords Basement membrane;Cell adhesion;Disulfide bond;Extracellular matrix;Glycoprotein;Reference proteome;Secreted
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000250}.
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 54,235
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda