Detail Information for IndEnz0002001356
IED ID IndEnz0002001356
Enzyme Type ID protease001356
Protein Name Tubulointerstitial nephritis antigen-like
Glucocorticoid-inducible protein 5
Oxidized LDL-responsive gene 2 protein
OLRG-2
Tubulointerstitial nephritis antigen-related protein
TIN Ag-related protein
TIN-Ag-RP
Gene Name TINAGL1 GIS5 LCN7 OLRG2 TINAGL PP6614 PSEC0088 UNQ204/PRO230
Organism Homo sapiens (Human)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human)
Enzyme Sequence MWRCPLGLLLLLPLAGHLALGAQQGRGRRELAPGLHLRGIRDAGGRYCQEQDLCCRGRADDCALPYLGAICYCDLFCNRTVSDCCPDFWDFCLGVPPPFPPIQGCMHGGRIYPVLGTYWDNCNRCTCQENRQWQCDQEPCLVDPDMIKAINQGNYGWQAGNHSAFWGMTLDEGIRYRLGTIRPSSSVMNMHEIYTVLNPGEVLPTAFEASEKWPNLIHEPLDQGNCAGSWAFSTAAVASDRVSIHSLGHMTPVLSPQNLLSCDTHQQQGCRGGRLDGAWWFLRRRGVVSDHCYPFSGRERDEAGPAPPCMMHSRAMGRGKRQATAHCPNSYVNNNDIYQVTPVYRLGSNDKEIMKELMENGPVQALMEVHEDFFLYKGGIYSHTPVSLGRPERYRRHGTHSVKITGWGEETLPDGRTLKYWTAANSWGPAWGERGHFRIVRGVNECDIESFVLGVWGRVGMEDMGHH
Enzyme Length 467
Uniprot Accession Number Q9GZM7
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: May be implicated in the adrenocortical zonation and in mechanisms for repressing the CYP11B1 gene expression in adrenocortical cells. This is a non catalytic peptidase C1 family protein (By similarity). {ECO:0000250}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Alternative sequence (6); Chain (1); Disulfide bond (5); Domain (1); Erroneous initiation (2); Glycosylation (2); Natural variant (1); Sequence conflict (2); Signal peptide (1)
Keywords Alternative splicing;Direct protein sequencing;Disulfide bond;Glycoprotein;Reference proteome;Secreted;Signal
Interact With O95429; P59991; Q99697-2; O75360; Q15645; P59991; Q9BYR5; Q7Z3S9; Q93062; Q15645
Induction
Subcellular Location SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10799322, ECO:0000269|PubMed:11170462}.
Modified Residue
Post Translational Modification PTM: Glycosylated. {ECO:0000269|PubMed:11170462, ECO:0000269|PubMed:19159218}.
Signal Peptide SIGNAL 1..21; /evidence="ECO:0000269|PubMed:11170462, ECO:0000269|PubMed:15340161"
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID 12482659; 15231748; 16169070; 16189514; 20711500; 21988832; 25416956; 25514977; 25521548; 30612941;
Motif
Gene Encoded By
Mass 52,387
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda