| IED ID | IndEnz0002001356 |
| Enzyme Type ID | protease001356 |
| Protein Name |
Tubulointerstitial nephritis antigen-like Glucocorticoid-inducible protein 5 Oxidized LDL-responsive gene 2 protein OLRG-2 Tubulointerstitial nephritis antigen-related protein TIN Ag-related protein TIN-Ag-RP |
| Gene Name | TINAGL1 GIS5 LCN7 OLRG2 TINAGL PP6614 PSEC0088 UNQ204/PRO230 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MWRCPLGLLLLLPLAGHLALGAQQGRGRRELAPGLHLRGIRDAGGRYCQEQDLCCRGRADDCALPYLGAICYCDLFCNRTVSDCCPDFWDFCLGVPPPFPPIQGCMHGGRIYPVLGTYWDNCNRCTCQENRQWQCDQEPCLVDPDMIKAINQGNYGWQAGNHSAFWGMTLDEGIRYRLGTIRPSSSVMNMHEIYTVLNPGEVLPTAFEASEKWPNLIHEPLDQGNCAGSWAFSTAAVASDRVSIHSLGHMTPVLSPQNLLSCDTHQQQGCRGGRLDGAWWFLRRRGVVSDHCYPFSGRERDEAGPAPPCMMHSRAMGRGKRQATAHCPNSYVNNNDIYQVTPVYRLGSNDKEIMKELMENGPVQALMEVHEDFFLYKGGIYSHTPVSLGRPERYRRHGTHSVKITGWGEETLPDGRTLKYWTAANSWGPAWGERGHFRIVRGVNECDIESFVLGVWGRVGMEDMGHH |
| Enzyme Length | 467 |
| Uniprot Accession Number | Q9GZM7 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: May be implicated in the adrenocortical zonation and in mechanisms for repressing the CYP11B1 gene expression in adrenocortical cells. This is a non catalytic peptidase C1 family protein (By similarity). {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Alternative sequence (6); Chain (1); Disulfide bond (5); Domain (1); Erroneous initiation (2); Glycosylation (2); Natural variant (1); Sequence conflict (2); Signal peptide (1) |
| Keywords | Alternative splicing;Direct protein sequencing;Disulfide bond;Glycoprotein;Reference proteome;Secreted;Signal |
| Interact With | O95429; P59991; Q99697-2; O75360; Q15645; P59991; Q9BYR5; Q7Z3S9; Q93062; Q15645 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10799322, ECO:0000269|PubMed:11170462}. |
| Modified Residue | |
| Post Translational Modification | PTM: Glycosylated. {ECO:0000269|PubMed:11170462, ECO:0000269|PubMed:19159218}. |
| Signal Peptide | SIGNAL 1..21; /evidence="ECO:0000269|PubMed:11170462, ECO:0000269|PubMed:15340161" |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 12482659; 15231748; 16169070; 16189514; 20711500; 21988832; 25416956; 25514977; 25521548; 30612941; |
| Motif | |
| Gene Encoded By | |
| Mass | 52,387 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |