Detail Information for IndEnz0002001357
IED ID IndEnz0002001357
Enzyme Type ID protease001357
Protein Name Tubulointerstitial nephritis antigen-like
Adrenocortical zonation factor 1
AZ-1
Androgen-regulated gene 1 protein
Tubulointerstitial nephritis antigen-related protein
TARP
Gene Name Tinagl1 Arg1 Lcn7 Tinagl
Organism Mus musculus (Mouse)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse)
Enzyme Sequence MWGCWLGLLLLLLAGQAALEARRSRWRRELAPGLHLRGIRDAGGRYCQEQDMCCRGRADECALPYLGATCYCDLFCNRTVSDCCPDFWDFCLGIPPPFPPVQGCMHGGRIYPVFGTYWDNCNRCTCHEGGHWECDQEPCLVDPDMIKAINRGNYGWQAGNHSAFWGMTLDEGIRYRLGTIRPSSTVMNMNEIYTVLGQGEVLPTAFEASEKWPNLIHEPLDQGNCAGSWAFSTAAVASDRVSIHSLGHMTPILSPQNLLSCDTHHQQGCRGGRLDGAWWFLRRRGVVSDNCYPFSGREQNEASPTPRCMMHSRAMGRGKRQATSRCPNGQVDSNDIYQVTPAYRLGSDEKEIMKELMENGPVQALMEVHEDFFLYQRGIYSHTPVSQGRPEQYRRHGTHSVKITGWGEETLPDGRTIKYWTAANSWGPWWGERGHFRIVRGTNECDIETFVLGVWGRVGMEDMGHH
Enzyme Length 466
Uniprot Accession Number Q99JR5
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: May be implicated in the adrenocortical zonation and in mechanisms for repressing the CYP11B1 gene expression in adrenocortical cells. This is a non catalytic peptidase C1 family protein. {ECO:0000269|PubMed:12600995}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Chain (1); Disulfide bond (5); Domain (1); Frameshift (1); Glycosylation (2); Signal peptide (1)
Keywords Disulfide bond;Glycoprotein;Reference proteome;Secreted;Signal
Interact With
Induction INDUCTION: Down-regulated in prostate after castration. {ECO:0000269|PubMed:11377975}.
Subcellular Location SUBCELLULAR LOCATION: Secreted.
Modified Residue
Post Translational Modification PTM: Glycosylated. {ECO:0000250}.
Signal Peptide SIGNAL 1..21; /evidence=ECO:0000255
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID 11217851; 12466851; 17425658; 18554416; 19587330; 19776386; 20562862; 21085487; 21267068; 22159717; 22987638; 23021200; 24006456; 26522507; 27480124; 28071719; 30612941; 31323030;
Motif
Gene Encoded By
Mass 52,665
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda