| IED ID | IndEnz0002001359 |
| Enzyme Type ID | protease001359 |
| Protein Name |
Transmembrane emp24 domain-containing protein 1 Interleukin-1 receptor-like 1 ligand Putative T1/ST2 receptor-binding protein p24 family protein gamma-1 Tp24 p24gamma1 |
| Gene Name | TMED1 IL1RL1L IL1RL1LG |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MMAAGAALALALWLLMPPVEVGGAGPPPIQDGEFTFLLPAGRKQCFYQSAPANASLETEYQVIGGAGLDVDFTLESPQGVLLVSESRKADGVHTVEPTEAGDYKLCFDNSFSTISEKLVFFELIFDSLQDDEEVEGWAEAVEPEEMLDVKMEDIKESIETMRTRLERSIQMLTLLRAFEARDRNLQEGNLERVNFWSAVNVAVLLLVAVLQVCTLKRFFQDKRPVPT |
| Enzyme Length | 227 |
| Uniprot Accession Number | Q13445 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Potential role in vesicular protein trafficking, mainly in the early secretory pathway. May act as a cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and may be involved in vesicle coat formation at the cytoplasmic side. Plays a positive role in IL-33-mediated IL-8 and IL-6 production by interacting with interleukin-33 receptor IL1RL1 (PubMed:23319592). Plays also a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26 (PubMed:32614325). {ECO:0000269|PubMed:23319592, ECO:0000269|PubMed:32614325}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Coiled coil (1); Domain (1); Motif (2); Mutagenesis (2); Natural variant (1); Signal peptide (1); Topological domain (2); Transmembrane (1) |
| Keywords | 3D-structure;Cell membrane;Coiled coil;Direct protein sequencing;Endoplasmic reticulum;Golgi apparatus;Immunity;Innate immunity;Membrane;Protein transport;Reference proteome;Signal;Transmembrane;Transmembrane helix;Transport |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:8621446}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:10852829, ECO:0000269|PubMed:12237308, ECO:0000269|PubMed:23319592}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:10852829, ECO:0000269|PubMed:12237308}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:12237308}; Single-pass type I membrane protein {ECO:0000255}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..23; /evidence="ECO:0000269|PubMed:19892738, ECO:0007744|PubMed:25944712" |
| Structure 3D | X-ray crystallography (1) |
| Cross Reference PDB | 7RRM; |
| Mapped Pubmed ID | 11466339; 15231748; 23416715; 23455153; 25609649; 26496610; 34634369; |
| Motif | MOTIF 218..227; /note=COPI vesicle coat-binding; /evidence=ECO:0000255; MOTIF 218..219; /note=COPII vesicle coat-binding; /evidence=ECO:0000255 |
| Gene Encoded By | |
| Mass | 25,206 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |