Detail Information for IndEnz0002001359
IED ID IndEnz0002001359
Enzyme Type ID protease001359
Protein Name Transmembrane emp24 domain-containing protein 1
Interleukin-1 receptor-like 1 ligand
Putative T1/ST2 receptor-binding protein
p24 family protein gamma-1
Tp24
p24gamma1
Gene Name TMED1 IL1RL1L IL1RL1LG
Organism Homo sapiens (Human)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human)
Enzyme Sequence MMAAGAALALALWLLMPPVEVGGAGPPPIQDGEFTFLLPAGRKQCFYQSAPANASLETEYQVIGGAGLDVDFTLESPQGVLLVSESRKADGVHTVEPTEAGDYKLCFDNSFSTISEKLVFFELIFDSLQDDEEVEGWAEAVEPEEMLDVKMEDIKESIETMRTRLERSIQMLTLLRAFEARDRNLQEGNLERVNFWSAVNVAVLLLVAVLQVCTLKRFFQDKRPVPT
Enzyme Length 227
Uniprot Accession Number Q13445
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: Potential role in vesicular protein trafficking, mainly in the early secretory pathway. May act as a cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and may be involved in vesicle coat formation at the cytoplasmic side. Plays a positive role in IL-33-mediated IL-8 and IL-6 production by interacting with interleukin-33 receptor IL1RL1 (PubMed:23319592). Plays also a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26 (PubMed:32614325). {ECO:0000269|PubMed:23319592, ECO:0000269|PubMed:32614325}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Chain (1); Coiled coil (1); Domain (1); Motif (2); Mutagenesis (2); Natural variant (1); Signal peptide (1); Topological domain (2); Transmembrane (1)
Keywords 3D-structure;Cell membrane;Coiled coil;Direct protein sequencing;Endoplasmic reticulum;Golgi apparatus;Immunity;Innate immunity;Membrane;Protein transport;Reference proteome;Signal;Transmembrane;Transmembrane helix;Transport
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:8621446}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:10852829, ECO:0000269|PubMed:12237308, ECO:0000269|PubMed:23319592}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:10852829, ECO:0000269|PubMed:12237308}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:12237308}; Single-pass type I membrane protein {ECO:0000255}.
Modified Residue
Post Translational Modification
Signal Peptide SIGNAL 1..23; /evidence="ECO:0000269|PubMed:19892738, ECO:0007744|PubMed:25944712"
Structure 3D X-ray crystallography (1)
Cross Reference PDB 7RRM;
Mapped Pubmed ID 11466339; 15231748; 23416715; 23455153; 25609649; 26496610; 34634369;
Motif MOTIF 218..227; /note=COPI vesicle coat-binding; /evidence=ECO:0000255; MOTIF 218..219; /note=COPII vesicle coat-binding; /evidence=ECO:0000255
Gene Encoded By
Mass 25,206
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda