| IED ID |
IndEnz0002001360 |
| Enzyme Type ID |
protease001360 |
| Protein Name |
Suppressor/enhancer of lin-12 protein 9
|
| Gene Name |
sel-9 W02D7.7 |
| Organism |
Caenorhabditis elegans |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Bilateria
Protostomia
Ecdysozoa
Nematoda (roundworms)
Chromadorea
Rhabditida
Rhabditina
Rhabditomorpha
Rhabditoidea
Rhabditidae
Peloderinae
Caenorhabditis
Caenorhabditis elegans
|
| Enzyme Sequence |
MNSLTWILAVLFVTPAASYFIHVDANEEQCFFDRLTSGTKMGLMFEVAEGGFLDIDVKITGPDNKEIYKGERESSGKFTFAAHMDGVYTYCFGNKMSTMTPKAVMFTVEITEPHQQAPGAAANQDAADNAKLEEMVRELSSALMSVKHEQEYMEVRERVHRNINENTNSRVVMWAAFEAFVLVGMTVGQIFYLKRFFEVRTMV |
| Enzyme Length |
203 |
| Uniprot Accession Number |
O17528 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
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| Calcium Binding |
|
| catalytic Activity |
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| DNA Binding |
|
| EC Number |
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| Enzyme Function |
FUNCTION: May have a role in the negative regulation of lin-12 and glp-1 transport to the cell surface (PubMed:10366590). May also have a role in a quality control mechanism for endoplasmic reticulum-Golgi transport; the budding of coatomer-coated and other species of coated vesicles, could bind cargo molecules to collect them into budding vesicles (PubMed:10366590). Involved in regulating the expression of proteasomal subunits such as rpt-3 in order to confer resistance to proteasomal dysfunction (PubMed:27528192). {ECO:0000269|PubMed:10366590, ECO:0000269|PubMed:27528192}. |
| Temperature Dependency |
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| PH Dependency |
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| Pathway |
|
| nucleotide Binding |
|
| Features |
Chain (1); Domain (1); Mutagenesis (5); Signal peptide (1); Topological domain (2); Transmembrane (1) |
| Keywords |
Cytoplasmic vesicle;ER-Golgi transport;Golgi apparatus;Membrane;Protein transport;Reference proteome;Signal;Transmembrane;Transmembrane helix;Transport |
| Interact With |
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| Induction |
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| Subcellular Location |
SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, COPI-coated vesicle membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Note=Golgi-derived coatomer-coated vesicles. |
| Modified Residue |
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| Post Translational Modification |
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| Signal Peptide |
SIGNAL 1..18; /evidence=ECO:0000255 |
| Structure 3D |
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| Cross Reference PDB |
- |
| Mapped Pubmed ID |
12529635;
14551910;
15338614;
17417969;
17486083;
17850180;
17897480;
20439776;
21177967;
22560298;
23800452;
25487147;
8293978;
|
| Motif |
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| Gene Encoded By |
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| Mass |
22,986 |
| Kinetics |
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| Metal Binding |
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| Rhea ID |
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| Cross Reference Brenda |
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