Detail Information for IndEnz0002001362
IED ID IndEnz0002001362
Enzyme Type ID protease001362
Protein Name Thylakoidal processing peptidase 1, chloroplastic
EC 3.4.21.89
Signal peptidase I-1
Gene Name TPP1 At2g30440 T6B20.20
Organism Arabidopsis thaliana (Mouse-ear cress)
Taxonomic Lineage cellular organisms Eukaryota Viridiplantae Streptophyta Streptophytina Embryophyta Tracheophyta Euphyllophyta Spermatophyta Magnoliopsida Mesangiospermae eudicotyledons Gunneridae Pentapetalae rosids malvids Brassicales Brassicaceae Camelineae Arabidopsis Arabidopsis thaliana (Mouse-ear cress)
Enzyme Sequence MAIRITFTYSTHVARNLVGTRVGPGGYCFESLVRPRFFSHKRDFDRSPRNRPASMYGSIARELIGEGSQSPLVMGLISILKSTTGHESSTMNVLGVSSFKASSIIPFLQGSKWIKNPPVIDDVDKGGTVCDDDDDKESRNGGSGWVNKLLSVCSEDAKAAFTAVTVSILFRSALAEPKSIPSTSMYPTLDKGDRVMAEKVSYFFRKPEVSDIVIFKAPPILLEYPEYGYSSNDVFIKRIVASEGDWVEVRDGKLFVNDIVQEEDFVLEPMSYEMEPMFVPKGYVFVLGDNRNKSFDSHNWGPLPIENIVGRSVFRYWPPSKVSDTIYHDQAITRGPVAVS
Enzyme Length 340
Uniprot Accession Number O04348
Absorption
Active Site ACT_SITE 184; /evidence=ECO:0000250
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.; EC=3.4.21.89;
DNA Binding
EC Number 3.4.21.89
Enzyme Function FUNCTION: Cleaves the thylakoid-transfer domain from a chloroplast protein. {ECO:0000269|PubMed:9422718}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (1); Chain (1); Erroneous gene model prediction (1); Topological domain (1); Transit peptide (2); Transmembrane (1)
Keywords Chloroplast;Hydrolase;Membrane;Plastid;Protease;Reference proteome;Thylakoid;Transit peptide;Transmembrane;Transmembrane helix
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Plastid, chloroplast thylakoid membrane {ECO:0000269|PubMed:9422718}; Single-pass membrane protein {ECO:0000269|PubMed:9422718}. Note=located in the non-appressed lamellae of the thylakoid network. {ECO:0000250}.
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID 14576160; 16895613; 22087276; 23288562; 23727204; 27247031;
Motif
Gene Encoded By
Mass 37,853
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda