Detail Information for IndEnz0002001376
IED ID IndEnz0002001376
Enzyme Type ID protease001376
Protein Name Tripeptidyl-peptidase 2
TPP2
EC 3.4.14.10
Tripeptidyl aminopeptidase
Tripeptidyl peptidase II
TPPII
Gene Name tpp-2 F21H12.6
Organism Caenorhabditis elegans
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Nematoda (roundworms) Chromadorea Rhabditida Rhabditina Rhabditomorpha Rhabditoidea Rhabditidae Peloderinae Caenorhabditis Caenorhabditis elegans
Enzyme Sequence MIVIRNWQRISYLSFCRFSTRSLSIQQFQKTPLLLVVRQQGSARLKMTSSPPEIVPQQPLDALLLNKTDTEQEIFLTKYPNYDGRDILIAILDTGVDPSLPGMQVTTTGERKMFDVIDCSGAGDVDTSITRTVKDGVIEGISGRKLAIPEKWKCPTGQYHVGLKPIFELYTKGVKSRVISERKEDVVGPSHNIAASEALKQLTEHEKVVGGTSEKTSDKWAREDFACKVDFLKSMASVADVGPVADVVTWHDGEMWRVCIDTSFRGRLGLGNVLGTFRETGDYAYLTNKDSVVYTVRVSPDGNLTEIVVPSGAHGSHVAGIAAANYPDNPQKNGLAPGAKILSLNIGDHRLGAMETGQAMTRAFNMCAELNVDIINMSFGEGTHLPDVGRVIEEARRLINRRGVIYVCSAGNQGPALSTVGAPGGTTTGVIGIGAYLTSESADTLYGVYKPVESSIYPWSSRGPCQDGKLGVSLVAPAAAFAGVPQYCRQSMQMMNGTSMSSPNAAGNVACMLSGLKQNNLKWTPYTVRMALENTAYMLPHIESFSQGQGMIKIATAYEKLSEILVNKVFPPRLTHFEINVSNHCKKSKGVYVREPNWNGPQEFTIGVEPIFQNHLSDNNLPAISFEKQIILQSTAPWVSHPQTMFVVAQERTMVVTVDASKAPKGANYTEIVGIDTADPSLGPIFRIPVTVINPEKVAVDQYTSRLVGKSGVTERRFVEVPSWATSAKITLRSTNKDEMDRFTLHTVYIEDDKCSRNTETQKIQGPIGNEWSKSITVQGGKTLEACVVRAWSRGKNPVDVDMTIDFFGVKKPTSISLIHGATNTPIRFQAAPTKSIDVSPSISLKSLVVSLKPQSAKVEPLGPRDMFLTSGLQINRLLLTYQLKVQKPSEVQLQLAGLTPYLYESPVDCVLFQIFGANKSFVGASSSYPDRWTQKLEKGDYTIQAQIRYPDDQVLQGMKELPLLVHVKLGNKISVDLAASASDATLGKECKFAGKALLPNQEMTVYAMNIADDKLPKTIVPTSGSFLAGTFSALKDSDLSDVDKSEVIYFLSEYSTRPTKGLSMVTTKKDTNQNQEMTDAIRDLEVSWVQKLTDEKAAKEFFEACLQKYPDHLPLLQNRVKQLMQAKLVDQTPENVQKIIELCGQILQITKPNETLQFSSVKQEHDDDLLTVDKWLALTGGSEDQRKDVVKLISQFEERKKSIILALQALSSLEQDIEVRKSKFDVPASLRFGGITPLIFGGKQGEVINKKSEGYEALKSKSEQIDATVSEELKKLDSNWTGNQFYVKLLVWLSADDTKTALISAKHAAALGQFGRCAKLLNKAGDELKSSATDSQAVDTSLAEVCESLEWNHLATHFKNSALIKNRTSYRLF
Enzyme Length 1374
Uniprot Accession Number Q09541
Absorption
Active Site ACT_SITE 93; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU01240; ACT_SITE 314; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU01240; ACT_SITE 499; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU01240
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=Release of an N-terminal tripeptide from a polypeptide.; EC=3.4.14.10; Evidence={ECO:0000250|UniProtKB:P29144};
DNA Binding
EC Number 3.4.14.10
Enzyme Function FUNCTION: Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway (By similarity). Has a role in regulation of fat storage. {ECO:0000250, ECO:0000269|PubMed:17932511}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (3); Chain (1); Domain (1)
Keywords Aminopeptidase;Hydrolase;Protease;Reference proteome;Serine protease
Interact With
Induction
Subcellular Location
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID 10778742; 21085631; 21177967; 21367940; 22267497; 22560298; 23800452; 24884423; 25487147; 25635455; 26009280; 27506200; 6593563;
Motif
Gene Encoded By
Mass 151,089
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda