| IED ID | IndEnz0002001385 |
| Enzyme Type ID | protease001385 |
| Protein Name |
Transmembrane protease serine 3 EC 3.4.21.- Serine protease TADG-12 Tumor-associated differentially-expressed gene 12 protein |
| Gene Name | TMPRSS3 ECHOS1 TADG12 UNQ323/PRO382 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MGENDPPAVEAPFSFRSLFGLDDLKISPVAPDADAVAAQILSLLPLKFFPIIVIGIIALILALAIGLGIHFDCSGKYRCRSSFKCIELIARCDGVSDCKDGEDEYRCVRVGGQNAVLQVFTAASWKTMCSDDWKGHYANVACAQLGFPSYVSSDNLRVSSLEGQFREEFVSIDHLLPDDKVTALHHSVYVREGCASGHVVTLQCTACGHRRGYSSRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDLYLPKSWTIQVGLVSLLDNPAPSHLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNEMIQPVCLPNSEENFPDGKVCWTSGWGATEDGAGDASPVLNHAAVPLISNKICNHRDVYGGIISPSMLCAGYLTGGVDSCQGDSGGPLVCQERRLWKLVGATSFGIGCAEVNKPGVYTRVTSFLDWIHEQMERDLKT |
| Enzyme Length | 454 |
| Uniprot Accession Number | P57727 |
| Absorption | |
| Active Site | ACT_SITE 257; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 304; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 401; /note=Charge relay system; /evidence=ECO:0000305 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.21.- |
| Enzyme Function | FUNCTION: Probable serine protease that plays a role in hearing. Acts as a permissive factor for cochlear hair cell survival and activation at the onset of hearing and is required for saccular hair cell survival (By similarity). Activates ENaC (in vitro). {ECO:0000250, ECO:0000269|PubMed:12393794}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Alternative sequence (6); Chain (1); Disulfide bond (10); Domain (3); Glycosylation (1); Mutagenesis (1); Natural variant (12); Sequence conflict (4); Site (1); Topological domain (2); Transmembrane (1) |
| Keywords | Alternative splicing;Autocatalytic cleavage;Deafness;Disease variant;Disulfide bond;Endoplasmic reticulum;Glycoprotein;Hydrolase;Membrane;Non-syndromic deafness;Protease;Reference proteome;Serine protease;Signal-anchor;Transmembrane;Transmembrane helix;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12393794}; Single-pass type II membrane protein {ECO:0000269|PubMed:12393794}. |
| Modified Residue | |
| Post Translational Modification | PTM: Undergoes autoproteolytic activation. |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 16169070; 21988832; |
| Motif | |
| Gene Encoded By | |
| Mass | 49,405 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |