| IED ID | IndEnz0002001386 |
| Enzyme Type ID | protease001386 |
| Protein Name |
Transmembrane protease serine 3 EC 3.4.21.- |
| Gene Name | Tmprss3 |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MGENDPPAAEAPFSFRSLFGLDDLKISPVAPDGDAVAAQILSLLPLKFFPIIVIGIIALILALAIGLGIHFDCSGKYRCHSSFKCIELTARCDGVSDCKNAEDEYRCVRVSGQRAALQVFTAAAWRTMCSDDWKSHYAKIACAQLGFPSYVSSDHLRVDALEEQFQGDFVSINHLLSDDKVTALHHSVYMREGCTSGHVVTLKCSACGTRTGYSPRIVGGNMSSLTQWPWQVSLQFQGYHLCGGSIITPLWIVTAAHCVYDLYHPKSWTVQVGLVSLMDSPVPSHLVEKIIYHSKYKPKRLGNDIALMKLSEPLTFDETIQPICLPNSEENFPDGKLCWTSGWGATEDGGDASPVLNHAAVPLISNKICNHRDVYGGIISPSMLCAGYLKGGVDSCQGDSGGPLVCQERRLWKLVGATSFGIGCAEVNKPGVYTRITSFLDWIHEQLERDLKT |
| Enzyme Length | 453 |
| Uniprot Accession Number | Q8K1T0 |
| Absorption | |
| Active Site | ACT_SITE 257; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 304; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 400; /note=Charge relay system; /evidence=ECO:0000305 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.21.- |
| Enzyme Function | FUNCTION: Probable serine protease that plays a role in hearing. Acts as a permissive factor for cochlear hair cell survival and activation at the onset of hearing and is required for saccular hair cell survival. Activates ENaC (in vitro). {ECO:0000269|PubMed:12393794, ECO:0000269|PubMed:21454591}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Alternative sequence (1); Chain (1); Disulfide bond (10); Domain (3); Glycosylation (1); Sequence conflict (2); Site (1); Topological domain (2); Transmembrane (1) |
| Keywords | Alternative splicing;Disulfide bond;Endoplasmic reticulum;Glycoprotein;Hydrolase;Membrane;Protease;Reference proteome;Serine protease;Signal-anchor;Transmembrane;Transmembrane helix;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12393794, ECO:0000269|PubMed:21454591}; Single-pass type II membrane protein {ECO:0000269|PubMed:12393794, ECO:0000269|PubMed:21454591}. |
| Modified Residue | |
| Post Translational Modification | PTM: Undergoes autoproteolytic activation. |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 11707078; 12466854; 12466855; 16141072; 16428450; 17918732; 20562862; 21677750; 21937810; 23255163; 24924414; 32186779; |
| Motif | |
| Gene Encoded By | |
| Mass | 49,506 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |