| IED ID |
IndEnz0002001394 |
| Enzyme Type ID |
protease001394 |
| Protein Name |
Triabin
|
| Gene Name |
|
| Organism |
Meccus pallidipennis (Triatomine bug) (Triatoma pallidipennis) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Bilateria
Protostomia
Ecdysozoa
Panarthropoda
Arthropoda
Mandibulata
Pancrustacea
Hexapoda
Insecta
Dicondylia
Pterygota (winged insects)
Neoptera
Paraneoptera
Hemiptera
Prosorrhyncha (bugs)
Heteroptera (true bugs)
Euheteroptera
Neoheteroptera
Panheteroptera
Cimicomorpha
Reduvioidea
Reduviidae (assassin bugs)
Triatominae (kissing bugs)
Meccus
Meccus pallidipennis (Triatomine bug) (Triatoma pallidipennis)
|
| Enzyme Sequence |
MKTIIAVTIFGILTCAYAAEGDDCSIEKAMGDFKPEEFFNGTWYLAHGPGVTSPAVCQKFTTSGSKGFTQIVEIGYNKFESNVKFQCNQVDNKNGEQYSFKCKSSDNTEFEADFTFISVSYDNFALVCRSITFTSQPKEDDYLVLERTKSDTDPDAKEIC |
| Enzyme Length |
160 |
| Uniprot Accession Number |
Q27049 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Thrombin inhibitor, forms a non-covalent complex with thrombin at a molar ratio of 1:1, inhibits thrombin-induced platelet aggregation, and prolongs thrombin clotting time and activated partial thromboplastin time. It only minimally suppresses the amidolytic activity of thrombin. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Beta strand (10); Chain (1); Disulfide bond (3); Helix (3); Natural variant (8); Signal peptide (1); Turn (1) |
| Keywords |
3D-structure;Blood coagulation;Direct protein sequencing;Disulfide bond;Hemostasis;Protease inhibitor;Secreted;Serine protease inhibitor;Signal |
| Interact With |
|
| Induction |
|
| Subcellular Location |
SUBCELLULAR LOCATION: Secreted. |
| Modified Residue |
|
| Post Translational Modification |
|
| Signal Peptide |
SIGNAL 1..18 |
| Structure 3D |
X-ray crystallography (1) |
| Cross Reference PDB |
1AVG;
|
| Mapped Pubmed ID |
- |
| Motif |
|
| Gene Encoded By |
|
| Mass |
17,860 |
| Kinetics |
|
| Metal Binding |
|
| Rhea ID |
|
| Cross Reference Brenda |
|