| IED ID | IndEnz0002001404 |
| Enzyme Type ID | protease001404 |
| Protein Name |
Probable tape measure protein Tail protein pb2 |
| Gene Name | D18-19 T5.140 T5p136 |
| Organism | Escherichia phage T5 (Enterobacteria phage T5) |
| Taxonomic Lineage | Viruses Duplodnaviria Heunggongvirae Uroviricota Caudoviricetes Caudovirales Demerecviridae Markadamsvirinae Tequintavirus Escherichia phage T5 (Enterobacteria phage T5) |
| Enzyme Sequence | MTDKLIRELLIDVKQKGATRTAKSIENVSDALENAAAASELTNEQLGKMPRTLYSIERAADRAAKSLTKMQASRGMAGITKSIDGIGDKLDYLAIQLIEVTDKLEIGFDGVSRSVKAMGNDVAAATEKVQDRLYDTNRALGGTSKGFNDTAGAAGRASRALGNTSGSARGATRDFAAMAKIGGRLPIMYAALASNVFVLQTAFESLKVGDQLNRLEQFGTIVGTMTGTPVQTLALSLQNATNGAISFEEAMRQASSASAYGFDSEQLEQFGLVARRAAAVLGVDMTDALNRVIKGVSKQEIELLDELGVTIRLNDAYENYVKQLNATSTGIKYTVDSLTTYQKQQAYANEVIAESTRRFGYLDDALKATSWEQFAANANSALRSLQQSAATYLNPVMDTLNTFLYQTKSSQMRVSAMARSASAKTTPAENVTALIENAVGAREDLDTYLKESEERVKKAQELKQQLDDLKAKQAATAPIANALTAGGIGGDESNKLVVQLTNELARQNKEIEERTKTEKVLRQAVQDTGEALLRNGKLAEQLGAKMKYADTAVPGDKGVFEVDPNNLKAVSEIQKNFDFLKKSSSDTANNIRMAASSITNAKKASSDLNSVVKAVEDTSKVTGQSADTLVKNLNLGFSSLDQMKAAQKGLSEYVTAMDKSEQNALEVAKRKDEVYNQTKDKAKAEAAAREVLLRQQQEQLTAAKALLAINPNDPEALKQVAKIETEILNTKAQGFENAKKTKDYTDKILGVDREIALLNDRTMTSTQYRLAQLRLELQLEQEKTELYSKQADGQAKVEQSRRAQAQISREIWEAEKQGTASHVSALMDALEVSQTQRNVTGQSQILTERLSILQQQLELSKGNTEEELKYRNEIYKTSAALEQLKKQRESQMQQQVGSSVGATYTPTTGLIGEDKDFADMQNRMASYDQAISKLSELNSEATAVAQSMGNLTNAMIQFSQGSLDTTSMIASGMQTVASMIQYSTSQQVSAIDQAIAAEQKRDGKSEASKAKLKKLEAEKLKIQQDAAKKQIIIQTAVAVMQAATAVPYPFSIPLMVAAGLAGALALAQASSASGMSSIADSGADTTQYLTLGERQKNVDVSMQASSGELSYLRGDKGIGNANSFVPRAEGGMMYPGVSYQMGEHGTEVVTPMVPMKATPNDQLSDGSKTTSGRPIILNISTMDAASFRDFASNNSTAFRDAVELALNENGTTLKSLGNS |
| Enzyme Length | 1219 |
| Uniprot Accession Number | Q6QGE7 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Fills the tail tube with its long coiled-coil domain and has pore-forming properties for host membrane penetration. Probable exolysin involved in host peptidoglycan digestion necessary for viral DNA entry into the host cell. Also functions as a tape measure protein that serves as a base for tail tube protein polymerization and acts as a template for tail length determination. {ECO:0000269|PubMed:18348984, ECO:0000269|PubMed:24198424}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Coiled coil (3); Propeptide (1); Site (1) |
| Keywords | Antimicrobial;Bacteriolytic enzyme;Coiled coil;Degradation of host cell envelope components during virus entry;Degradation of host peptidoglycans during virus entry;Late protein;Pore-mediated penetration of viral genome into host cell;Reference proteome;Viral genome ejection through host cell envelope;Viral long flexible tail ejection system;Viral penetration into host cytoplasm;Viral release from host cell;Viral tail assembly;Virion;Virus entry into host cell |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Virion {ECO:0000269|PubMed:24198424}. Note=Probably fills the tail tube with its coiled-coil domain and has its C-terminus within the tail tip. {ECO:0000269|PubMed:24198424}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 131,496 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |