| IED ID | IndEnz0002001414 |
| Enzyme Type ID | protease001414 |
| Protein Name |
Metalloprotease TIKI1 EC 3.4.-.- TRAB domain-containing protein 2A |
| Gene Name | trabd2a tiki1 |
| Organism | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amphibia Batrachia Anura Pipoidea Pipidae Xenopodinae Xenopus Silurana Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) |
| Enzyme Sequence | MVIIWNIFLPAFLLVLAKASLRSSRDSANCKLNKKQSQLNSFLWTIKRDPPSYFFGTIHVPYTRVWDFIPENSKTAFQQSNIVYFELDLTDPYTISALTSCQMLPQGENLQNVLPRDIYRRLKRHLEYVKLMMPSWMTPDQRGKGLYADYLFNAIAGNWERKRPVWVMLMVNSLTEVDIKSRGVPVLDLYLAQEAERLKKRTGAVEQVEEQCHPLNGLNLSQVIFALNQTLLQQENLRAGSVQVPYSTEDLIKHYNCGDLNSIIFNHDSSQVPNFINSTLPPQERITAQEIDNYFRQELIYKRNERMGKRVKDLLEQFPEKSFFFAFGAGHFLGNNTVIDVLKRYGYDVLHTPAGRSIINNGKGKKNLLPSKFSSSSLPVGLSAPPCTVTSRIKQSINSHKDQESLPDILLDDDIDQLDKDERKYKKRKQRKEKHRHFSDLWVRIQESSTDTTPQIRIINGYITVEPHPREHGKDKYIKAAQSVSFSLSIPSAFLLLAWCFQQVAVLQ |
| Enzyme Length | 508 |
| Uniprot Accession Number | F6PTN1 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.-.- |
| Enzyme Function | FUNCTION: Metalloprotease that acts as a negative regulator of the Wnt signaling pathway: expressed in the Spemann-Mangold organizer and is required for anterior-neural patterning in head formation in embryos. Acts by mediating the cleavage of the N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave wnt8. {ECO:0000269|PubMed:22726442}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Glycosylation (4); Signal peptide (1); Topological domain (2); Transmembrane (1) |
| Keywords | Cell membrane;Glycoprotein;Hydrolase;Membrane;Metal-binding;Metalloprotease;Protease;Reference proteome;Signal;Transmembrane;Transmembrane helix;Wnt signaling pathway |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..23; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 58,544 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |