| IED ID | IndEnz0002001456 |
| Enzyme Type ID | protease001456 |
| Protein Name |
Proteinase-activated receptor 4 PAR-4 Coagulation factor II receptor-like 3 Thrombin receptor-like 3 |
| Gene Name | F2RL3 PAR4 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDTLELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAAADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVHPLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASHWQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSNLLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSPGDTVASKASAEGGSRGMGTHSSLLQ |
| Enzyme Length | 385 |
| Uniprot Accession Number | Q96RI0 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation. {ECO:0000269|PubMed:10079109}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Beta strand (1); Chain (1); Compositional bias (1); Disulfide bond (1); Glycosylation (1); Mutagenesis (2); Natural variant (4); Propeptide (1); Region (2); Signal peptide (1); Site (1); Topological domain (8); Transmembrane (7) |
| Keywords | 3D-structure;Blood coagulation;Cell membrane;Disulfide bond;G-protein coupled receptor;Glycoprotein;Hemostasis;Membrane;Receptor;Reference proteome;Signal;Transducer;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. |
| Modified Residue | |
| Post Translational Modification | PTM: A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand. |
| Signal Peptide | SIGNAL 1..17; /evidence=ECO:0000255 |
| Structure 3D | X-ray crystallography (2) |
| Cross Reference PDB | 2ZPK; 3QDZ; |
| Mapped Pubmed ID | 10191087; 11907122; 12006403; 12008957; 12871418; 12888878; 13678420; 14521606; 14528298; 14973136; 15045135; 15078882; 15099288; 15152000; 15203717; 16102047; 1672265; 16754659; 16837456; 16952995; 17323377; 17373694; 18179608; 18427961; 18480058; 18577758; 18617639; 18682394; 18787202; 19053259; 1905813; 19058300; 19528350; 19667088; 19913121; 20155436; 20175118; 20230207; 20561531; 20628086; 20807173; 20930172; 21127289; 21164077; 21391917; 21461878; 21635966; 21649850; 22151913; 22228373; 22318735; 22411985; 22511653; 23307185; 23784669; 24097976; 24216752; 24723492; 24776597; 24990072; 25120239; 25239438; 25278289; 25293779; 25664811; 25821117; 25876034; 26020638; 26569550; 26878340; 26966273; 27126938; 27402844; 27784794; 28053157; 28126849; 28448853; 28453567; 29289806; 29357418; 29677491; 29722794; 30055940; 30143503; 30314721; 30574762; 3086311; 31217499; 31892516; 33812377; 34469011; 8290554; 8615752; 8664309; 873923; 8982657; 9087410; |
| Motif | |
| Gene Encoded By | |
| Mass | 41,133 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |