| IED ID | IndEnz0002001462 |
| Enzyme Type ID | protease001462 |
| Protein Name |
Vacuolar membrane protease EC 3.4.-.- FXNA-related family protease 1 |
| Gene Name | AFUA_1G05960 |
| Organism | Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Eurotiales (green and blue molds) Aspergillaceae Aspergillus Aspergillus subgen. Fumigati Neosartorya fumigata (Aspergillus fumigatus) Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) |
| Enzyme Sequence | MARPSLSPSNPLGFTPWPVTVITAVVYLALVVPLLVVHHVVPSAPSSSPKGLNLTEAWADLQELTHGFHPYNSHRNDEVHEWLLKRILELIDSAPPASEYGSVGEEKPDIVVFDDTQSNLTFSGRGSGLGVYFESTNIMVYIRGWEEDRERWWEDPHGRPAGKGGVLVNAHYDSVSTGYGATDDGVGVVSCLQLIKYFTTPGHVPRRGLVLLFNNGEEDFLNGARVYSQHPISQLPHTFLNLEGAGAGGRATLFRSSDAEVTKPYMRAPHPFGSVLSANGFEAGLISSQTDYVVFEGDLGLRGLDVAFMEPRARYHTDEDDARHTSLASVWHMLSAAVATTEGLVSDASSRFEGLPREDGRIASGSGPKGVWFDLFGSAFVVFELHTLFALSVTLLVVAPLVLLVTSIALARADKMYLFRSSASPEDSDGSEVVPLHGVRGFFRFPFLLVIPTAVTVGLAYLVTKFNPYIIHSSEYAVWSMMISAWVFLAWFVSRVADFARPSAFHRVYTLTWLFLVEWVFLVISTVYENQYGLAGGYFVLFVFAGTFLATWISYLELFALPRKSDYATQLALPSRRTSSHGSRLGTASGEDVEDGEDEDDDGTTAEATETTSLLRGQRTTFANYVRVTGDYLRDDDEEPRQPNLYGHEQAWSIHLPKWVWVLQFLLTAPLVLIFVGPLALLLTSALRQTGQDGSPSLFIYIAVAALTTLLFIPLLPFIHRYTHHIPLFLLCVFAGTLIYNLVAFPFSPANRLKLFFIQEVDLDTGVNHASLSGAYPFVHDVARRLPSTAGQNITCDLAMLRPKCSWHGIPPQVVQPAAASKMEDWLSYNITKSDSEPKAQLSISGRNTRACKVVFDRPVLDFQVADSAYDPRFPHVSPDGTKEIRLWSREWGHTWTVDVEWAADAEETDEKGPGLSGRVVCLWSDGNSAGVIPALDEVRRYAPVWAGVSKLSDGLVEGSRRFEV |
| Enzyme Length | 965 |
| Uniprot Accession Number | Q4WJH4 |
| Absorption | |
| Active Site | ACT_SITE 217; /note=Proton acceptor; /evidence=ECO:0000250|UniProtKB:P80561 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.-.- |
| Enzyme Function | FUNCTION: May be involved in vacuolar sorting and osmoregulation. {ECO:0000250|UniProtKB:P38244}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Compositional bias (1); Glycosylation (4); Metal binding (6); Region (1); Site (1); Topological domain (10); Transmembrane (9) |
| Keywords | Glycoprotein;Hydrolase;Membrane;Metal-binding;Metalloprotease;Protease;Reference proteome;Transmembrane;Transmembrane helix;Vacuole;Zinc |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250|UniProtKB:P38244}; Multi-pass membrane protein {ECO:0000255}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 106,578 |
| Kinetics | |
| Metal Binding | METAL 171; /note=Zinc 1; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 183; /note=Zinc 1; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 183; /note=Zinc 2; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 218; /note=Zinc 2; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 243; /note=Zinc 1; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 316; /note=Zinc 2; catalytic; /evidence=ECO:0000250|UniProtKB:P80561 |
| Rhea ID | |
| Cross Reference Brenda |