| IED ID | IndEnz0002001522 |
| Enzyme Type ID | protease001522 |
| Protein Name |
Signal peptide peptidase-like 2 OsSPPL2 EC 3.4.23.- |
| Gene Name | SPPL2 Os11g0433200 LOC_Os11g24540 OsJ_33780 |
| Organism | Oryza sativa subsp. japonica (Rice) |
| Taxonomic Lineage | cellular organisms Eukaryota Viridiplantae Streptophyta Streptophytina Embryophyta Tracheophyta Euphyllophyta Spermatophyta Magnoliopsida Mesangiospermae Liliopsida Petrosaviidae commelinids Poales Poaceae BOP clade Oryzoideae Oryzeae Oryzinae Oryza Oryza sativa (Rice) Oryza sativa subsp. japonica (Rice) |
| Enzyme Sequence | MATHHARRLPAAAAVLLLVLLAGGSAADDASSDDDAGVPPSPGCSNKFQLVKVKNWVNGTEGTIVVGLSARFGASVPRDIHEAQKTFAVLANPLDCCSNSTSKLTNYIAIAQRGECAFTAKAKIAQTGGAVGLLVINDNEELYKMVCSDNDTSINVTIPVVMIPQSAGKKMKGLLDQGARLEVQLYSPNRPVVDLSACFLWIMAIGTIVCASLWTEFVACEQVDERYNQLTRKDGPNSGTTNREDKEIFEISAKGAIVFILVASVFLLLLFYFMSSWFVWLLIVLFCIGGIEGMHVCLVTLLTRICKDCGQKTVQLPFFGEVLTLSVLIVPFCTIFAILWAVYRHASFAWIGQDILGICLMITVLQMARLPNIRVASALLSAAFVYDVFWVFISPLIFHESVMIAVARGDNSGEAIPMLLRIPRFFDPWGGYDMIGFGDIIFPGLLVAFSYRFDRASKRGLFNGYFLWLTVGYAVGLFLTYLALFLMDGHGQPALLYLVPCTLGLIVILGWFRGELHDLWNYGRSQTENLVDEP |
| Enzyme Length | 534 |
| Uniprot Accession Number | Q53P98 |
| Absorption | |
| Active Site | ACT_SITE 387; /evidence=ECO:0000250; ACT_SITE 439; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.23.- |
| Enzyme Function | FUNCTION: Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Domain (1); Erroneous gene model prediction (2); Glycosylation (4); Motif (1); Signal peptide (1); Topological domain (10); Transmembrane (9) |
| Keywords | Endosome;Glycoprotein;Hydrolase;Membrane;Protease;Reference proteome;Signal;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | PTM: Glycosylated. {ECO:0000250}. |
| Signal Peptide | SIGNAL 1..27; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | MOTIF 493..495; /note=PAL |
| Gene Encoded By | |
| Mass | 58,622 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |