| IED ID | IndEnz0002001524 |
| Enzyme Type ID | protease001524 |
| Protein Name |
ECF RNA polymerase sigma factor SigL ECF sigma factor SigL Alternative RNA polymerase sigma factor SigL RNA polymerase sigma-L factor Sigma-L factor |
| Gene Name | sigL MT0759 |
| Organism | Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) |
| Taxonomic Lineage | cellular organisms Bacteria Terrabacteria group Actinobacteria Actinomycetia (high G+C Gram-positive bacteria) Corynebacteriales Mycobacteriaceae Mycobacterium Mycobacterium tuberculosis complex Mycobacterium tuberculosis Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) |
| Enzyme Sequence | MARVSGAAAAEAALMRALYDEHAAVLWRYALRLTGDAAQAEDVVQETLLRAWQHPEVIGDTARPARAWLFTVARNMIIDERRSARFRNVVGSTDQSGTPEQSTPDEVNAALDRLLIADALAQLSAEHRAVIQRSYYRGWSTAQIATDLGIAEGTVKSRLHYAVRALRLTLQELGVTR |
| Enzyme Length | 177 |
| Uniprot Accession Number | P9WGH4 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | DNA_BIND 141..160; /note=H-T-H motif; /evidence=ECO:0000255 |
| EC Number | |
| Enzyme Function | FUNCTION: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); DNA binding (1); Motif (1); Region (2) |
| Keywords | DNA-binding;Sigma factor;Transcription;Transcription regulation;Virulence |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | MOTIF 42..45; /note=Interaction with polymerase core subunit RpoC; /evidence=ECO:0000250 |
| Gene Encoded By | |
| Mass | 19,538 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |