| IED ID | IndEnz0002001537 |
| Enzyme Type ID | protease001537 |
| Protein Name |
Serine proteinase inhibitor 2 Serp-2 Serpin-2 |
| Gene Name | SPI-2 VACWR195 B13R |
| Organism | Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) |
| Taxonomic Lineage | Viruses Varidnaviria Bamfordvirae Nucleocytoviricota Pokkesviricetes Chitovirales Poxviridae Chordopoxvirinae Orthopoxvirus Vaccinia virus Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) |
| Enzyme Sequence | MDIFREIASSMKGENVFISPASISSVLTILYYGANGSTAEQLSKYVEKEENMDKVSAQNISFKSINKVYGRYSAVFKDSFLRKIGDKFQTVDFTDCRTIDAINKCVDIFTEGKINPLLDEPLSPDTCLLAISAVYFKAKWLTPFEKEFTSDYPFYVSPTEMVDVSMMSMYGKAFNHASVKESFGNFSIIELPYVGDTSMMVILPDKIDGLESIEQNLTDTNFKKWCNSLEATFIDVHIPKFKVTGSYNLVDTLVKSGLTEVFGSTGDYSNMCNSDVSVDAMIHKTYIDVNEEYTEAAAATCALVSDCASTITNEFCVDHPFIYVIRHVDGKILFVGRYCSPTTNC |
| Enzyme Length | 345 |
| Uniprot Accession Number | P15059 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Inhibits the proteolytic activity of interleukin 1-beta converting enzyme (ICE) and ICE-like enzymes. Can also block apoptosis through host tumor necrosis factor (TNF) receptor. {ECO:0000269|PubMed:8709286, ECO:0000269|PubMed:9049422}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Site (1) |
| Keywords | Early protein;Host cytoplasm;Host-virus interaction;Inhibition of host caspases by virus;Modulation of host cell apoptosis by virus;Protease inhibitor;Reference proteome;Serine protease inhibitor |
| Interact With | |
| Induction | INDUCTION: Expressed in the early phase of the viral replicative cycle. {ECO:0000269|PubMed:7831769}. |
| Subcellular Location | SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000305}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 22810585; |
| Motif | |
| Gene Encoded By | |
| Mass | 38,537 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |