| IED ID | IndEnz0002001571 |
| Enzyme Type ID | protease001571 |
| Protein Name |
Kunitz-type protease inhibitor 1 Hepatocyte growth factor activator inhibitor type 1 HAI-1 |
| Gene Name | SPINT1 HAI1 UNQ223/PRO256 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MAPARTMARARLAPAGIPAVALWLLCTLGLQGTQAGPPPAPPGLPAGADCLNSFTAGVPGFVLDTNASVSNGATFLESPTVRRGWDCVRACCTTQNCNLALVELQPDRGEDAIAACFLINCLYEQNFVCKFAPREGFINYLTREVYRSYRQLRTQGFGGSGIPKAWAGIDLKVQPQEPLVLKDVENTDWRLLRGDTDVRVERKDPNQVELWGLKEGTYLFQLTVTSSDHPEDTANVTVTVLSTKQTEDYCLASNKVGRCRGSFPRWYYDPTEQICKSFVYGGCLGNKNNYLREEECILACRGVQGGPLRGSSGAQATFPQGPSMERRHPVCSGTCQPTQFRCSNGCCIDSFLECDDTPNCPDASDEAACEKYTSGFDELQRIHFPSDKGHCVDLPDTGLCKESIPRWYYNPFSEHCARFTYGGCYGNKNNFEEEQQCLESCRGISKKDVFGLRREIPIPSTGSVEMAVAVFLVICIVVVVAILGYCFFKNQRKDFHGHHHHPPPTPASSTVSTTEDTEHLVYNHTTRPL |
| Enzyme Length | 529 |
| Uniprot Accession Number | O43278 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Inhibitor of HGF activator. Also acts as an inhibitor of matriptase (ST14). |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Alternative sequence (1); Beta strand (19); Chain (1); Disulfide bond (9); Domain (4); Glycosylation (3); Helix (6); Natural variant (3); Sequence conflict (2); Signal peptide (1); Site (2); Turn (4) |
| Keywords | 3D-structure;Alternative splicing;Direct protein sequencing;Disulfide bond;Glycoprotein;Protease inhibitor;Reference proteome;Repeat;Secreted;Serine protease inhibitor;Signal |
| Interact With | Q08AM2; Q8TD06; O75508; Q9BXN2-6; Q92520; P21145; Q9NVC3; Q9NRQ5; P02787; Q9BVC6; Q8WZ59; Q5BJF2; Q86UF1; Q9UHD9; O75841; O95183 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..35; /evidence=ECO:0000269|PubMed:15340161 |
| Structure 3D | NMR spectroscopy (1); X-ray crystallography (6) |
| Cross Reference PDB | 1YC0; 2MSX; 4ISL; 4ISN; 4ISO; 5EZD; 5H7V; |
| Mapped Pubmed ID | 11013244; 1280830; 12815039; 15231748; 15324701; 15792801; 15994391; 16044910; 16103126; 16273651; 16713569; 16820046; 17389401; 17786295; 17981575; 18713750; 18769935; 18813126; 1885621; 19148468; 19222607; 19223533; 19535514; 19578736; 20213201; 20228799; 20696767; 20715109; 20716618; 20977675; 21123732; 21795523; 21875933; 21898507; 22023801; 22031598; 22087277; 22118498; 23393351; 23409135; 23443661; 23979832; 24147538; 24409221; 24659667; 25510835; 25842366; 25925948; 26165838; 26166362; 27189939; 27226587; 27356668; 27992572; 28348076; 28618968; 28817220; 29046355; 29202869; 29438412; 29532159; 29976755; 30087389; 31558918; 32415092; 33486722; 34185790; 34381422; 8346233; 9346890; |
| Motif | |
| Gene Encoded By | |
| Mass | 58,398 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |