| IED ID | IndEnz0002001591 |
| Enzyme Type ID | protease001591 |
| Protein Name |
Serine protease inhibitor A3G Serpin A3G Serine protease inhibitor 2A Serpin 2A |
| Gene Name | Serpina3g Spi2A |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MAGVSPAVFGCPDVTLGRNTAVREVQENVTSVDSLTLVSSNTDFAFSLYRKLVLKNPDENVVFSPFSICTALALLSLGAKSNTLKEILEGLKFNLTETPEPDIHQGFRYLLDLLSQPGNQVQISTGSALFIEKHLQILAEFKEKARALYQAEAFTADFQQPLKATKLINDYVSNHTQGKIKELISGLKESTLMVLVNYIYFKGKWKNPFDPNDTFKSEFYLDEKRSVIVSMMKTGYLTTPYFRDEELSCTVVELKYTGNASAMFILPDQGRMQQVEASLQPETLRKWKNSLKPRMIHELRLPKFSISTDYSLEHILPELGIREVFSTQADLSAITGTKDLRVSQVVHKAVLDVAETGTEAAAATGMAGVGCCAVFDFLEIFFNRPFLMIISDTKAHIALFMAKVTNPERSMNFPNGEGASSQRLESKRLCFGDPLCLIGQ |
| Enzyme Length | 440 |
| Uniprot Accession Number | Q5I2A0 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Serine and cysteine protease inhibitor. Can inhibit lysosomal papain-like proteases including the cathepsins B, G, H, K, L and V. Ineffective against elastase, granzyme A, granzyme B, or caspases 3, 8 or 9. Inhibition of cytoplasmic cathepsin B following release from the lysosome may protect cells from apoptosis. This may facilitate the survival of progenitor T-cells and the subsequent development of long term memory CD8 T-cells. {ECO:0000269|PubMed:14517268, ECO:0000269|PubMed:15225607, ECO:0000269|PubMed:15311278}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Region (1); Sequence conflict (3); Site (1) |
| Keywords | Adaptive immunity;Apoptosis;Cytoplasm;Immunity;Nucleus;Protease inhibitor;Reference proteome;Serine protease inhibitor;Thiol protease inhibitor |
| Interact With | |
| Induction | INDUCTION: Induction during apoptosis requires NF-kappa-B, a heterodimer of RELA- and NFKB1. {ECO:0000269|PubMed:14517268}. |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm. Nucleus. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 11217851; 12051830; 12466851; 15485925; 15795238; 16141072; 16804897; 1718822; 1991447; 20338168; 22745374; 23319700; 24964278; 24973688; 29106998; |
| Motif | |
| Gene Encoded By | |
| Mass | 49,021 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |