IED ID | IndEnz0002001630 |
Enzyme Type ID | protease001630 |
Protein Name |
Proteasome subunit beta 1 EC 3.4.25.1 20S proteasome beta subunit 1 Proteasome core protein PsmB 1 |
Gene Name | psmB1 Saci_0662 |
Organism | Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) |
Taxonomic Lineage | cellular organisms Archaea TACK group Crenarchaeota Thermoprotei Sulfolobales Sulfolobaceae Sulfolobus Sulfolobus acidocaldarius Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) |
Enzyme Sequence | MEELPATAIGIKTKDGVVLAAERRLSYGDFVLSKSARKVFKLGRFGIAGAGIVGDIQTLTRIMNVEIKYYEMYNSRKISARAAAKLLSVILYQNKVLPYISELLFGGVDEDGPKLFILDPIGSLIEDSYAAVGSGARVAIGVLEAEYNESLTSEAAKELAIKSMKSAVERDVMSGDGIDILIINKNNIYEDFIKI |
Enzyme Length | 195 |
Uniprot Accession Number | Q4JAY3 |
Absorption | |
Active Site | ACT_SITE 7; /note=Nucleophile; /evidence=ECO:0000255|HAMAP-Rule:MF_02113 |
Activity Regulation | ACTIVITY REGULATION: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity. {ECO:0000255|HAMAP-Rule:MF_02113}. |
Binding Site | |
Calcium Binding | |
catalytic Activity | CATALYTIC ACTIVITY: Reaction=Cleavage of peptide bonds with very broad specificity.; EC=3.4.25.1; Evidence={ECO:0000255|HAMAP-Rule:MF_02113}; |
DNA Binding | |
EC Number | 3.4.25.1 |
Enzyme Function | FUNCTION: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. {ECO:0000255|HAMAP-Rule:MF_02113}. |
Temperature Dependency | |
PH Dependency | |
Pathway | |
nucleotide Binding | |
Features | Active site (1); Chain (1); Propeptide (1) |
Keywords | 3D-structure;Autocatalytic cleavage;Cytoplasm;Hydrolase;Protease;Proteasome;Reference proteome;Threonine protease;Zymogen |
Interact With | |
Induction | |
Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_02113}. |
Modified Residue | |
Post Translational Modification | |
Signal Peptide | |
Structure 3D | X-ray crystallography (1) |
Cross Reference PDB | 6Z46; |
Mapped Pubmed ID | 32764038; |
Motif | |
Gene Encoded By | |
Mass | 21,231 |
Kinetics | |
Metal Binding | |
Rhea ID | |
Cross Reference Brenda |