| IED ID | IndEnz0002001648 |
| Enzyme Type ID | protease001648 |
| Protein Name |
Serpin B5 Maspin Peptidase inhibitor 5 PI-5 |
| Gene Name | SERPINB5 PI5 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MDALQLANSAFAVDLFKQLCEKEPLGNVLFSPICLSTSLSLAQVGAKGDTANEIGQVLHFENVKDVPFGFQTVTSDVNKLSSFYSLKLIKRLYVDKSLNLSTEFISSTKRPYAKELETVDFKDKLEETKGQINNSIKDLTDGHFENILADNSVNDQTKILVVNAAYFVGKWMKKFSESETKECPFRVNKTDTKPVQMMNMEATFCMGNIDSINCKIIELPFQNKHLSMFILLPKDVEDESTGLEKIEKQLNSESLSQWTNPSTMANAKVKLSIPKFKVEKMIDPKACLENLGLKHIFSEDTSDFSGMSETKGVALSNVIHKVCLEITEDGGDSIEVPGARILQHKDELNADHPFIYIIRHNKTRNIIFFGKFCSP |
| Enzyme Length | 375 |
| Uniprot Accession Number | P36952 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Alternative sequence (2); Beta strand (15); Chain (1); Glycosylation (4); Helix (14); Natural variant (3); Sequence conflict (2); Site (1); Turn (11) |
| Keywords | 3D-structure;Alternative splicing;Direct protein sequencing;Glycoprotein;Reference proteome;Secreted |
| Interact With | Q9Y6M0 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted, extracellular space. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | X-ray crystallography (4) |
| Cross Reference PDB | 1WZ9; 1XQG; 1XQJ; 1XU8; |
| Mapped Pubmed ID | 11751384; 11788595; 11969337; 12037665; 12127964; 12220518; 12231537; 12366809; 12384513; 12425757; 12533266; 12629351; 12644823; 12753703; 12786889; 12789271; 12799381; 12964023; 12969792; 14532972; 14534696; 14578190; 14670180; 14716296; 14732229; 14991928; 15009909; 15145521; 15197584; 15256060; 15309707; 15353310; 15492782; 15501821; 15578720; 15608662; 15620951; 15688005; 15713631; 15731774; 15907209; 16007219; 16049007; 16203989; 16227634; 16304843; 16329135; 16491398; 16540429; 16604823; 16633061; 16720730; 16892558; 16936308; 17189399; 17203179; 17203770; 17301947; 17446556; 17458898; 17490717; 18042077; 18060631; 18091325; 18091326; 18234645; 18236066; 18247378; 18343598; 18367129; 18597952; 18665036; 18698492; 18931702; 19090015; 19147537; 19148518; 19221500; 19222699; 19309490; 19462894; 19473451; 19596235; 19728335; 19906413; 19909580; 19966016; 20075396; 20092039; 20099971; 20105109; 20132554; 20211623; 20334895; 20336301; 20337574; 20346150; 20349288; 20360068; 20363977; 20459532; 20697987; 20939879; 21048031; 21069375; 21109985; 21187389; 21330826; 21365746; 21439064; 21502940; 21606500; 21617230; 21622623; 21725612; 21732742; 21833477; 21855619; 21856005; 21903246; 21943228; 22011669; 22076034; 22292406; 22684556; 22780967; 22825520; 22857708; 22963136; 23079206; 23115015; 23271290; 23410722; 23717449; 23730906; 23818344; 23922175; 23923074; 23924927; 24002600; 24030740; 24114705; 24223769; 24228118; 24242003; 24346847; 24581141; 24607789; 24772914; 24801268; 25040445; 25098993; 25322663; 25358722; 25459315; 25553975; 25640309; 25775950; 25936422; 25973067; 25973084; 25977386; 26051724; 26067133; 26080829; 26095742; 26124368; 26208903; 26263377; 26296971; 26329803; 26362203; 26456962; 26490978; 26497917; 26526579; 26614844; 26733306; 26757744; 27177016; 27221742; 27297724; 27409165; 27525723; 27704157; 27888098; 28009978; 28011488; 28031066; 28064070; 28339463; 28405681; 28648644; 28780084; 28870936; 29126758; 29363056; 29715131; 30035819; 30737971; 30740890; 31002675; 31228474; 31986422; 32005234; 32079044; 32391971; 32746986; 33300360; 33691472; 33952482; 34475084; 34624458; |
| Motif | |
| Gene Encoded By | |
| Mass | 42,100 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |