| IED ID | IndEnz0002001670 |
| Enzyme Type ID | protease001670 |
| Protein Name |
Serine-repeat antigen protein 6 EC 3.4.22.- Cysteine protease SERA6 |
| Gene Name | SERA6 PF3D7_0207500 |
| Organism | Plasmodium falciparum (isolate 3D7) |
| Taxonomic Lineage | cellular organisms Eukaryota Sar Alveolata Apicomplexa Aconoidasida Haemosporida (haemosporidians) Plasmodiidae Plasmodium Plasmodium (Laverania) Plasmodium falciparum Plasmodium falciparum (isolate 3D7) |
| Enzyme Sequence | MICPIFFLYIINVLFTQYFIKCEGNKVTVISHNNGHNDNLDVNKNGVISQENVFDTSESLNLPSNKKVGSDDLNTTTISFTVPDNLENEVKVVSSSESGKGATVSHTKVTSEGLSDTQPNVTQSVSSSTHTPGSLDSTMSTEQHSSVSQSSLPTESSSETLNKATVPEIPIQINSGLLKNYNGVKVTGSCGSYFRVYLVPHILIYALTKYSVIQLESLFNDNARIDVEHKGELQNKCSEGYHFKLVVYITHNVLNLKWKTYKPNEESKSEDSDVRKYRIPKLERPFTSIQVYTANSKAGVIETKNYNIRTDIPDTCDAIATDCFLNGNVNIEKCFQCTLLVQKKDKSHECFKYVSSEMKKKMNEIKVKAQDDFNPNEYKLIESIDNILSKIYKKANKPFEISKDLINLEDLDYQFKNELLEYCKLLKKVDTSGTLEEYELGNAEDIYNNLTRLLKSHSDENIVTLQGKLRNTAICIKNVDEWILNKRGLTLPSESPSESSSKSDSYLNTFNDKDKNEDKDDMSKNSKEEFKNDDKENSDDQNNNDSNKKDDENNINNGDTNYVYDFDDDDYDNNSYEKDMYESPIKENKNGVIDLEKYGNQIKLKSPYFKNSKYCNYEYCNRWRDKTSCISQIEVEEQGNCGLCWIFASKLHFETIRCMRGYGHFRSSALYVANCSKRKPIDRCEEGSNPLEFLRILDEKKFLPLESNYPYSYTSAGNSCPKLPNSWTNLWGDTKLLFNKKVHRYIGNKGFISHETSYFKNNMDLFIDMVKREVQNKGSVIIYIKTQDVIGYDFNGKGVHSMCGDRTPDHAANIIGYGNYINKKGEKRSYWLIRNSWSYYWGDEGNFRVDMLGPKNCLYNFIHTVVFFKLDLGTIHVPKKKSWKKNVYFLRHNPDFMYSLYYNNYEPETSQDFESENDYDNAFVHGQSNESDETNKEGKNVHNSVEKKIQILHILKHIKDSQIKRGLVKYDNINETKDEHTCSRVNSQDAEKYEECKKFCLTKWNECKDHYSPGYCLTDLYKGEDCNFCYV |
| Enzyme Length | 1031 |
| Uniprot Accession Number | Q9TY96 |
| Absorption | |
| Active Site | ACT_SITE 644; /evidence=ECO:0000255|PROSITE-ProRule:PRU10088; ACT_SITE 810; /evidence=ECO:0000250|UniProtKB:O60911; ACT_SITE 835; /evidence=ECO:0000250|UniProtKB:O60911 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.22.- |
| Enzyme Function | FUNCTION: Cysteine protease which plays an essential role in merozoite egress from host erythrocytes. May cleave host SPTB/beta spectrin and ANK1/ankyrin-1 which disrupts host erythrocyte actin cytoskeleton and leads to host erythrocyte cell membrane rupture. {ECO:0000250|UniProtKB:Q26015}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Compositional bias (2); Glycosylation (8); Region (2); Signal peptide (1); Site (3) |
| Keywords | Glycoprotein;Hydrolase;Membrane;Protease;Reference proteome;Signal;Thiol protease;Zymogen |
| Interact With | Q8I0V0 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Parasitophorous vacuole lumen {ECO:0000269|PubMed:22984267}. Parasitophorous vacuole membrane {ECO:0000269|PubMed:22984267}; Peripheral membrane protein {ECO:0000305}. |
| Modified Residue | |
| Post Translational Modification | PTM: Just prior to merozoite egress from host erythrocytes, proteolytically cleaved by SUB1 to generate the active 75kDa form. {ECO:0000269|PubMed:18083098, ECO:0000269|PubMed:22984267}. |
| Signal Peptide | SIGNAL 1..24; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 16267556; |
| Motif | |
| Gene Encoded By | |
| Mass | 118,836 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |