Detail Information for IndEnz0002001701
IED ID IndEnz0002001701
Enzyme Type ID protease001701
Protein Name Metalloproteinase inhibitor 3
Tissue inhibitor of metalloproteinases 3
TIMP-3
Gene Name TIMP3
Organism Scyliorhinus torazame (Cloudy catshark)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Chondrichthyes Elasmobranchii (elasmobranchs) Selachii (sharks) Galeomorphii Galeoidea Carcharhiniformes (ground sharks) Scyliorhinidae (cat sharks) Scyliorhinus Scyliorhinus torazame (Cloudy catshark)
Enzyme Sequence MVFSTTAALSLLLALSSMQLSEVSEACTCMPNHPQEAFCNSDIVIRAKVVGKKLLKDGPFGTMRYTIKQMKMYRGFSKMQQVQYIYTEAAESLCGVRLQVNKFQYLITGRVFDGEVYTGVCNFIVPWDRLTLSQRKGLNHRYQYGCNCKIKPCYYLPCFVTAKNECFWTDMLSDQGYMGHQAKHYVCIRQKEGYCSWYRGAAPPDKTRINATDP
Enzyme Length 214
Uniprot Accession Number Q9W6B4
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli (By similarity). {ECO:0000250}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Chain (1); Disulfide bond (6); Domain (1); Glycosylation (1); Metal binding (1); Region (2); Signal peptide (1); Site (1)
Keywords Disulfide bond;Extracellular matrix;Glycoprotein;Metal-binding;Metalloenzyme inhibitor;Metalloprotease inhibitor;Protease inhibitor;Secreted;Signal;Zinc
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Modified Residue
Post Translational Modification
Signal Peptide SIGNAL 1..26; /evidence=ECO:0000255
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 24,498
Kinetics
Metal Binding METAL 27; /note=Zinc; via amino nitrogen and carbonyl oxygen; shared with metalloproteinase partner; /evidence=ECO:0000250|UniProtKB:P16035
Rhea ID
Cross Reference Brenda